新型脂肪因子与肥胖相关代谢性疾病  

Novel adipokines and obesity-related metabolic diseases

作　　者：张娴[1] 陈宏[1] Zhang Xian;Chen Hong.(Department of Endo- crinology and Metabolism, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China)

机构地区：[1]南方医科大学珠江医院内分泌代谢科,广州510282

出　　处：《国际内分泌代谢杂志》2018年第3期171-175,共5页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金（81570716,8177030041）;广东省自然科学基金（2016A030313633）

摘　　要：肥胖是一种慢性低度炎性反应疾病，与代谢性疾病风险增加密切相关。研究表明，脂肪组织在体内代谢平衡调节中具有关键作用，不仅参与能量存储，并作为关键的内分泌器官，分泌具有促炎或抗炎活性的脂肪因子，参与胰岛素抵抗、2型糖尿病的发生。近期发现的几种新型脂肪细胞因子，如spexin、slit家族、adipolin、Wntl诱导型信号通路蛋白2等在调节糖、脂代谢以及炎性反应等方面具有重要作用。Obesity is a chronic low-grade inflammatory disease, which is closely related to the increased risk of metabolic diseases. Adipose tissue has been shown to play an essential role in regulating met- abolic balance. Adipose tissue is not only involved in energy storage, but also as a key endocrine organ with secretion of pro-inflammatory or anti-inflammatory adipokines, participates in the occurrence of insulin resist- ance and type 2 diabetes mellitus. Recently, several novel types of cytokines have been found to play impor- tant roles in regulating glucose and lipid metabolism and inflammation, such as spexin, slit family, adipolin, Wntl inducible signaling pathway protein 2, and so on.

关 键 词：脂肪组织 脂肪因子 肥胖 2型糖尿病 能量代谢 

分 类 号：R589.2[医药卫生—内分泌]