蛙皮素样受体亚型-3与代谢综合征  

Bombesin receptor subtype-3 and metabolic syndrome

作　　者：谢幸[1] 陈树春[2] 朱海娇[1] 刘阳[3] 王幸[1] Xie Xing;Chen Shuchun;Zhu Haijiao;Liu Yang;Wang Xing(Graduate School of Hebei Medical University, Shifiazhuang 050017, China)

机构地区：[1]河北医科大学研究生学院,石家庄050017 [2]河北省人民医院内分泌一科,石家庄050051 [3]河北北方学院研究生部,张家口075000

出　　处：《国际内分泌代谢杂志》2018年第3期176-178,182,共4页International Journal of Endocrinology and Metabolism

摘　　要：蛙皮素样受体家族的蛙皮素样受体亚型-3（BRS-3）是一种G蛋白耦联受体,主要存在于中枢神经系统和外周组织.研究发现,BRS-3基因敲除小鼠有糖代谢受损、基础代谢率降低、摄食与吸收增加、体重增加、胰岛素分泌增加、胰岛素抵抗、轻度高血压等一系列代谢性因素的变化.2型糖尿病合并肥胖人群的脂肪细胞、骨骼肌细胞中BRS-3 mRNA与蛋白质表达水平是减少的.研究发现,BRS-3激动剂有刺激胰岛素分泌、增加基础代谢率等作用,从而可能为治疗肥胖、2型糖尿病等代谢性疾病提供一个新思路.The bombesin-like receptor subtype-3 （BRS-3）,a member of the bombesin-like receptor family,is a G-protein coupled receptor mainly found in the central nervous system and peripheral tissues.The study found that BRS-3 gene knockout mice had impaired glucose metabolism,decreased basal metabolic rate,increased food intake and absorption,weight gain,increased insulin secretion,insulin resistance,mild hypertension and a series of metabolic changes.In patients with type 2 diabetes mellitus and obesity,the expression of BRS-3 mRNA and protein in adipocytes,skeletal muscle cells have decreased.Studies found that BRS-3 agonists could stimulate insulin secretion,increase basal metabolic rate,which may provide a new insight for the treatment of metabolic disease such as obesity,type 2 diabetes.

关 键 词：蛙皮素样受体亚型-3 2型糖尿病 肥胖 代谢综合征 

分 类 号：R589[医药卫生—内分泌]