血清抑制素B联合性激素检测在显微取精术术前评估中的临床意义  

Clinical significance of serum inhibin B combined with sex hormone in preoperative evaluation of MD-TESE

作　　者：巨清华 姜卫[2] 李森 聂晨阳 罗涌 李富东 张斌 王养民 周逢海 常德辉 罗国雄 JU Qinghua1 ,JIANG Wei2,LI Sen3 ,NIE Chenyang3 ,LUO Yong3 ,LI Fudong1 ,ZHANG Bin1,3 , WANG Yangmin1 , ZHOU Fenghai1 , CHANG Dehui1 , LUO Guoxiong1.(1. Lanzhou General Hospital of PLA, Lanzhou 730050, China; 2. Air Force Hangzhou Aeromedieal Appraisal Training Center; 3.The PLA Hospital of Hong Kon)

机构地区：[1]解放军兰州总医院,甘肃兰州730050 [2]空军杭州航空医学鉴定训练中心 [3]驻香港部队医院

出　　处：《西北国防医学杂志》2018年第4期221-223,共3页Medical Journal of National Defending Forces in Northwest China

基　　金：全军医药卫生科研资助项目(CLZ11JB09)

摘　　要：目的:探讨血清抑制素B(InhB)及性激素检测在显微取精术(MD-TESE)术前评估中的临床意义。方法:选取我科2017-01~11接受显微取精术的12例无精子症患者,依据术后是否成功取得精子,分为观察组及对照组,每组6例。采用双抗体夹心酶联免疫吸附法检测血清InhB、促卵泡成熟激素(FSH)、黄体生成素(LH)及睾酮(T)水平,并分析其在术前评估中的意义。结果:观察组血清InhB、T水平较对照组升高,而FSH、LH水平较对照组降低,差异均有统计学意义(P<0.05)。结论:血清InhB及性激素水平检测对于评估无精子症患者睾丸功能和预测显微取精术的结局,具有一定的临床应用价值。Objective：To investigate the clinical significance of serum inhibin B（InhB）combined with sex hormone in preoperative evaluation of microdissection testicular sperm extraction（MD-TESE）.Methods：Twelve patients with non-obstructive azoospermia（NOA）undergoing MD-TESE were admitted from January to November 2017,and the patients were divided into obeservation group and control group according to whether or not having sperm successfully.InhB,follicle-stimulating hormone（FSH）,luteinizing hormone（LH）and testosterone（T）in serum were detected by ELISA before and after MD-TESE,and the clinical significance of preoperative evaluation was analyzed.Results：The levels of InhB and T in observation group was higher than those in control group,the levels of FSH and LH in observation group was lower than those in control group,there was statistically significant difference（P〈0.05）.Conclusion：It could be helpful for evaluate of testicular function and predict of the outcome of MD-TESE in patients with NOA by detecting levels of InhB and sex hormone in serum,which may have a certain clinical application value.

关 键 词：睾丸显微取精术 血清抑制素B 性激素 

分 类 号：R699[医药卫生—泌尿科学]