枸橼酸咖啡因与氨茶碱治疗早产儿呼吸暂停临床疗效及安全性评价  

Evaluation of curative effect and safety of caffeine citrate combined with aminophylline in treatment of apnea of prematurity

作　　者：李艳秋[1] 李建军[1] LI Yan-Qiu;LI Jian-Jan(The Third People＇s Hospital of Mianyang , Mianyang , Sichuan 621000, China)

机构地区：[1]绵阳市第三人民医院,四川绵阳621000

出　　处：《中国妇幼保健》2018年第9期2035-2038,共4页Maternal and Child Health Care of China

摘　　要：目的研究枸橼酸咖啡因与氨茶碱治疗早产儿呼吸暂停(AOP)的临床疗效与安全性,为临床治疗提供参考。方法选取绵阳市第三人民医院2014年10月-2016年12月收治的100例呼吸暂停早产儿作为研究对象。根据随机数字表法分为对照组和观察组,每组50例。两组患儿均接受床旁心电监护、心率与呼吸监测、保暖、吸氧及辅助通气等常规治疗。对照组在常规治疗基础上加用氨茶碱,观察组在常规治疗基础上加用枸橼酸咖啡因,均治疗7d。观察两组患儿治疗效果及并发症发生率、药物不良反应及住院时间。结果对照组患儿治疗总有效率(78.0%)低于观察组(96.0%),差异有统计学意义(P<0.05);对照组患儿治疗期间视网膜病、支气管肺发育不良及脑损伤发生率均高于观察组,差异均有统计学意义(均P<0.05);两组患儿治疗期间新生儿呼吸窘迫综合征、贫血及坏死性小肠结肠炎发生率比较,差异均无统计学意义(均P>0.05);对照组患儿心动过速、多尿及低血钾发生率均高于观察组,差异均有统计学意义(均P<0.05);两组患儿体温升高、神经兴奋及喂养不耐受发生率比较,差异均无统计学意义(均P>0.05);对照组患儿住院时间高于观察组,差异有统计学意义(P<0.05)。结论采用枸橼酸咖啡因治疗早产儿呼吸暂停疗效显著,不良反应少,安全性高,能减少并发症发生,缩短患儿住院时间,可作为早产儿呼吸暂停治疗的首选药物。Objective To research the clinical efficacy and safety of caffeine citrate combined with aminophylline in treatment of apnea of prematurity,provide a reference for clinical treatment. Methods From October 2014 to December 2016,100 children with apnea of prematurity treated in the Third People’s Hospital of Mianyang were selected and divided into control group and observation group by random number table,50 children in each group. The children in the two groups were treated by routine therapy,including bedside electrocardiogram monitoring,heart rate and breath monitoring,keeping warmth,oxygen inhalation,and assisted ventilation. The children in control group were treated by aminophylline based on routine therapy,and the children in observation group were treated by caffeine citrate based on routine therapy. All the children in the two groups were treated for seven days. The curative effects,incidence rates of complications,drug adverse reactions,and hospitalization time in the two groups were observed. Results The total effective rate in control group was 78. 0%,which was statistically significantly lower than that in observation group(96. 0%）(P〈0. 05）. The incidence rates of retinopathy,bronchopulmonary dysplasia,and brain injury in control group during treatment were statistically significantly higher than those in observation group(P〈0. 05）.There was no statistically significant difference in the incidence rates of neonatal respiratory distress syndrome,anemia,and necrotizing enterocolitis during treatment between the two groups(P〉0. 05）. The incidence rates of tachycardia,polyuria,and hypokalemia in control group were statistically significantly higher than those in observation group(P〈 0. 05）. There was no statistically significant difference in the incidence rates of increased temperature,nervous excitation,and feeding intolerance between the two groups(P〉0. 05）. The hospitalization time in control group was statistically significantly higher than that in observation group(P〈0. 05�

关 键 词：枸橼酸咖啡因 氨茶碱 早产儿呼吸暂停 临床疗效 安全性 

分 类 号：R725[医药卫生—儿科]