聚类分析和Logistic回归分析对活动期溃疡性结肠炎症状规律的研究  

Study on the Traditional Chinese Medicine Symptoms Regularities of Active Ulcerative Colitis Based on Cluster Analysis and Logistic Regression Analysis

作　　者：李毅[1,2] 陈更生 刘艳 唐梦凡 孙婳[1] LI Yi;CHEN Gengsheng;LIU Yan;TANG Mengfan;SUN Hua(Shaanxi University of Chinese Medicine, Xianyang Shaanxi China 712046;Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang Shaanxi China 712000;The Fifth Geological and Mineral Exploration Institute Medical Office of Qinghai, Xining Qinghai China 810028)

机构地区：[1]陕西中医药大学,陕西咸阳712046 [2]陕西中医药大学附属医院,陕西咸阳712000 [3]青海省第五地质矿产勘查院医务所,青海西宁810028

出　　处：《中医学报》2018年第5期770-774,共5页Acta Chinese Medicine

基　　金：陕西省科技厅研究项目(2013JQ4009);陕西省教育厅研究项目(2014JK1200)

摘　　要：目的:研究聚类分析和Logistic回归分析在活动期溃疡性结肠炎中医症状组合规律研究中的应用。方法:采用自拟《溃疡性结肠炎的中医证候流行病学调查表》收集活动期溃疡性结肠炎患者324例,并行聚类分析和Logistic回归分析。结果:聚类分析得出大肠湿热证、寒滞肠胃证、肝郁脾虚证3类证候是溃疡性结肠炎活动期基本证候;Logistic回归分析提示:大肠湿热证主要症状为:苔黄腻、舌质红、脉滑数、里急后重、腹部灼痛等;次要症状为:痢下赤白脓血、烦热口渴等。寒滞肠胃证主要症状为:泄泻清稀、恶寒发热、苔薄白、苔白腻、水样便等;次要症状为:纳差、腹痛喜温等。肝郁脾虚证主要症状为:与情志有关、腹痛则泻、泻后痛减、脉弦、腹部胀痛等;次要症状为:胸胁胀闷、矢气较频等。结论:运用聚类分析和Logistic回归分析结合的多元统计方法筛选活动期溃疡性结肠炎基本中医证候的主要症状和次要症状,为该病中医辨证标准化研究提供了一种新的方法。Objective： To explore the application of cluster analysis and Logistic regression analysis in the study of TCM syndrome combination rules of active ulcerative colitis. Methods： Using self-made ＂ Ulcerative Colitis TCM Epidemiological Questionnaire＂,324 cases of active ulcerative colitis were collected and analyzed by Logistic regression and cluster analysis method. Results： By the cluster analysis,active ulcerative colitis was provided with 3 basic syndromes which were damp heat syndrome,stomach cold stagnation syndrome,liver stagnation and spleen deficiency syndrome; Logistic regression analysis showed that the main symptoms of damp heat syndrome was red tongue,yellow greasy fur,slippery pulse number,tenesmus and abdominal pain,and minor symptoms included red white purulent dysentery,heat vexation and thirst,et al. In addition,the main symptoms of cold stagnation syndrome was thin stomach diarrhea,fever,thin white fur,greasy,watery diarrhea,et al.,and the secondary symptoms included anorexia,abdominal pain,and thermophilic. The main symptoms of liver stagnation and spleen deficiency were emotional,abdominal pain,diarrhea,and pain reduction after diarrhea,and pulse string; the secondary symptoms included chest fullness,vector gas frequency and so on. Conclusion： Multivariate statistical analysis method combined with the cluster analysis and Logistic regression could screen out the primary and secondary symptoms of active ulcerative colitis in basic syndromes of traditional Chinese medicine,and providing a new method for the study of TCM standardization of the disease.

关 键 词：溃疡性结肠炎 聚类分析 LOGISTIC回归分析 症状 证候 

分 类 号：R259.746.2[医药卫生—中西医结合]