硼酸类化学传感器的研究进展  

Research Progress of Boronic Acid in Chemsensors

作　　者：王浩[1,2,3,4] 王凯 孙捷[1,2,3,4] 方桂迁[1,2,3,4] 姚庆强[1,2,3,4] 吴忠玉[1,2,3,4] Wang Hao;Wang Ka;Sun Jie;Fang Guiqian;Yao Qingqiang;Wu Zhongyu(School of Medicine and Life Sciences University of Jinan-Shandong Academy of Medical Sciences, Jinan 250200;Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062;Key Laboratory for Biotech-Drugs Ministry of Health, Jinan 250062;Key Laboratory of Rare and Uncommon Diseases of Shandong Province, Jinan 250062)

机构地区：[1]济南大学山东省医学科学院医学与生命科学学院,济南250200 [2]山东省医学科学院药物研究所,济南250062 [3]国家卫生部生物技术药物重点实验室,济南250062 [4]山东省罕少见病重点实验室,济南250062

出　　处：《有机化学》2018年第5期1035-1051,共17页Chinese Journal of Organic Chemistry

基　　金：山东省自然科学基金(No.ZR2014YL035)资助项目~~

摘　　要：检测和识别体内某些物质,例如唾液酸化LewisA/X,能够为疾病的诊断、治疗、预后、分子示踪及深入研究相关疾病机理等方面提供重要参考.因此,开发高选择性、高灵敏度的化学传感器具有重要价值.苯基硼酸化合物由于其特殊结构,能够与糖、儿茶酚胺以及氟化物、氰化物等路易斯碱相互作用,使得其能够作为传感器用于相关物质的荧光识别和检测;且此类化合物具有高选择性、高效能、分析速度快等优点.近几年,将硼酸与纳米粒子、量子点等新材料相结合,设计出性能更加优越的硼酸传感器.综述了硼酸类化合物在传感器方面的研究进展.The detection and fluorescent identification of some substances such as s Lea/x in vivo can provide important reference for the diagnosis,treatment and prognosis of disease,molecular tracing and further research on the mechanism of related diseases.Therefore,the development and discovery of high selectivity and high sensitivity chemsensors is of great value.Due to the special structure,phenyl boronic acid compounds could interact and bind with sugar,catecholamine containing catechol structure,fluoride or alkali cyanide.So boronic acids could be develeped as fluorescence sensors selectively for related substances,while have the advantages of high selectivity,high efficiency,rapid analysis and so on.In recent years,boronic acid has been functioned with new materials such as nanoparticles and quantum dots to design novel sensors for better performance.In this paper,the recent progress in the study of boronic acid compounds in sensors is reviewed.

关 键 词：硼酸 化学传感器 荧光 糖 电化学 

分 类 号：TP212.2[自动化与计算机技术—检测技术与自动化装置]