尿酸累积暴露与高血压发病的关系  

STUDY ON THE ASSOCIATION BETWEEN CUMULATIVE SERUM URIC ACID AND HYPERTENSION

作　　者：李丽娜 杨文浩[1] 舒荣[1] 宋海澄[1] 韩依轩[1] 崔刘福[1] 刘学军[2] 周靖[3] Li Lina;Yang Wenhao;Liu Xuejun(Department of Rheumatology and Immunology, Kailuan General Hospital, Tangshan 063000, Chin)

机构地区：[1]开滦总医院风湿免疫科,河北省唐山市063000 [2]唐山市工人医院 [3]开滦总医院肾内科

出　　处：《中国煤炭工业医学杂志》2018年第2期177-182,共6页Chinese Journal of Coal Industry Medicine

基　　金：唐山市科技计划项目(编号:15130244a)

摘　　要：目的研究尿酸累积暴露量(cumUA)对高血压发病情况的影响。方法以连续参加2006—2007、2008—2009、2010—2011、2012—2013年开滦集团公司四次健康体检的47 828例职工为研究对象,根据研究队列的纳入及排除标准,共15 592例有效数据纳入统计分析,其中男性10 382例,女性5 210例。根据每连续两次体检所测尿酸的均值及每连续两次体检的间隔时间计算尿酸累积暴露量(cumUA),根据cumUA的四分位数将观察对象分为四组,观察每组高血压发病情况,应用Logistic回归模型分析高血压发病的危险因素。结果最终纳入统计分析的15 592例观察对象中,2012—2013年体检时确诊高血压2 171例,高血压发病率为13.9%。男性确诊高血压1 579例,发病率15.2%,Q_1~Q_4组高血压发病率分别为10.3%(268例),13.0%(338例),16.9%(438例),20.6%(535例);女性确诊高血压592例,发病率11.4%,Q_1~Q_4组高血压发病率分别为8.9%(117例),9.6%(124例),12.2%(159例),14.8%(192例),同性别不同cumUA组间发病率差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,总人群及男性、女性人群高血压发病风险均随cumUA增加而上升,但女性仅Q_4组高血压发病风险的增加有统计学意义,OR值为1.39(95%CI:1.01~1.92)。结论随cumUA增加,高血压发病率及发病风险均呈上升趋势。Objective To investigate the effect of cumUA to the morbidity of hypertension.Methods A total of 47828 cases were as the study cohort who participated Kailuan health examination consecutively in 2006-2007,2008-2009,2010-2011 and 2012-2013.There were 15592 participants（10382 were male,5210 were female）with integral data recruited into the survey according to the criteria.Based on the average UA for each pair of consecutive examinations and the time between these two consecutive visits in years to calculate cumUA,then divided observed subjects into four groups according to the quartile of cumUA.The morbidity of hypertension was observed in each group,and the risk factors of hypertension were analyzed with Logistic regression method.Results 13.9%（2171 cases）of the 15592 subjects that with integral data recruited into the survey were diagnosed hypertension in 2012-2013.The morbidity of hypertension in group Q1-Q4 in male were 10.3%（268 cases）,13.0%（338 cases）,16.9%（438 cases）and 20.6%（535 cases）respectively;and in female were 8.9%（117 cases）,9.6%（124 cases）,12.2%（159 cases）and 14.8%（192 cases）respectively.The incidence of hypertension was statistically significant in the cumUA group of the same gender（P〈0.05）.Multiple Logistic regression analysis showed that the risk of hypertension in the general population,male and female populations was rise with the increase of cumUA,but the rise in the female only Q4 group was statistically significant,with an ORof 1.39（95% CI：1.01-1.92）.Conclusion With the increasing of cumUA,both morbidity and risk of hypertension have the tendency of rising.

关 键 词：尿酸 累积暴露 高血压 风险 

分 类 号：R181.32[医药卫生—流行病学]