一个金鸡纳碱衍生物的合成以及对靛红和硝基甲烷Henry反应的催化  

Synthesis of a New Quinine Derivative and Application in the Henry Reaction of Isatin and Nitromethane

作　　者：郭利杰[1] 付玉轩 胡珊珊 李小娟[1] Guo Lijie;Fu Xuxuan;Hu Shanshan;Li Xiaojuan(Xinjiang Normal University, College of Chemistry and Chemical Engineering, Urumqi 830054, Chin)

机构地区：[1]新疆师范大学化学化工学院,新疆乌鲁木齐830054

出　　处：《广东化工》2018年第9期261-262,共2页Guangdong Chemical Industry

摘　　要：用S-联二萘酚通过Mitsunobu反应与奎宁结合,制备1个新型金鸡纳碱催化剂。新催化剂结构:用质谱、核磁共振氢谱确定了目标化合物的结构,总收率达15%。将该催化剂用于靛红和硝基甲烷Henry反应,获得ee值9%,产率99%的加成产物。A new type of quinine catalyst was prepared via（S）-（-）-1,1＇-Bi（2-naphthol） and quinine by Mitsunobu reaction. The structure of new catalyst structuret compound was determined by mass spectrometry, nuclear magnetic resonance hydrogen spectrum, and the total yield was 15%. The catalyst was used for the Henry reaction of isatin and nitromethane, obtaining 9% of the ee value and 99% of the product yield.

关 键 词：Henry反应 不对称催化 S-联二萘酚 金鸡纳碱衍生物 

分 类 号：TQ[化学工程]