扶正抗癌方对化疗后胃肠道反应的影响  

The Influence of Decoction for Strengthening Genuine Qi and Anti-Cancer on Gastrointestinal Reaction After Chemotherapy

作　　者：王小龙[1] 徐彬[1] 周雷[1] 马俊杰[1,2] WANG Xiao-long;XU Bin;ZHOU Lei;MAJun-jie(Shuyang Hospital of TCM Attached to Nanjing University of TCM, Professor Chen Yiren Academic Inheritance Studio, Shuyang, Jiangsu, China, 223600;Nanjing University of TCM, Nanjing, Jiangsu, China, 210046)

机构地区：[1]南京中医药大学附属沭阳县中医院陈亦人教授学术传承工作室,江苏沭阳223600 [2]南京中医药大学,江苏南京210046

出　　处：《河南中医》2018年第5期734-737,共4页Henan Traditional Chinese Medicine

基　　金：宿迁市科技项目(编号:Z201517);江苏省中医药局课题项目(编号:LB13042)

摘　　要：目的:观察扶正抗癌方对化疗后胃肠道反应的影响。方法:选择2014年10月至2016年10月本院收治的中晚期恶性肿瘤患者46例,均经病理及影像学检查等确诊,符合NCCN临床实践指南诊断标准,随机分为治疗组和对照组,每组23例。对照组给予吗丁啉、奥美拉唑胶囊口服治疗,治疗组在化疗期间或化疗后给予扶正抗癌方治疗,两组均以14天为1个疗程,所有患者均至少治疗1个疗程。两组患者治疗前后检测血清白细胞介素-2(interleukin-2,IL-2),白细胞介素-5(interleukin-5,IL-5)水平。结果:治疗组有效率87.0%,对照组有效率56.5%,治疗组有效率优于对照组,差异有统计学意义(P<0.05);治疗组治疗后中医证候积分优于对照组,差异有统计学意义(P<0.05);治疗组治疗后IL-2、IL-5水平优于对照组,差异有统计学意义(P<0.05)。结论:扶正抗癌方治疗恶性肿瘤化疗后胃肠道反应有较好疗效,能明显减轻化疗药物消化道副反应,提高肿瘤患者化疗后生存质量。Objective： To observe the influence of Decoction for Strengthening Genuine Qi and Anti-Cancer on gastrointestinal reaction after chemotherapy. Methods： Forty-six patients with middle and late malignant tumor who were treated in our hospital from October 2014 to October 2016 were selected and all were confirmed by pathological and imaging examination. They were in accordance with the standard of NCCN clinical practice guide,and were randomly divided into the treatment group and the control group,with 23 cases in each group. The ones in the control group were given oral administration of domoridin and omeprazole,and the ones in the treatment group were given Decoction for Strengthening Genuine Qi and Anti-Cancer during or after chemotherapy. The two groups were treated with for 14 days as one course. All the patients were treated at least one course. The serum levels of interleukin-2(IL-2） and interleukin-5(IL-5） were detected in two groups before and after the treatment. Results：The effective rate of the treatment group was 87%,and that of the control group was 56. 5%,the effective rate of the treatment group was better than the control group(P〈0. 05）. The TCM syndrome score of the treatment group was better than the control group after the treatment(P〈0. 05）,and the levels of IL-2 and IL-5 in the treatment group were better than those of the control group(P〈0. 05）. Conclusion： Decoction for Strengthening Genuine Qi and Anti-Cancer has a remarkable clinical curative effect on gastrointestinal reaction after chemotherapy,can significantly reduce the side effects of chemotherapy drugs and improve the quality of life of cancer patients after chemotherapy.

关 键 词：恶性肿瘤 化疗 扶正抗癌方 胃肠道反应 

分 类 号：R273[医药卫生—中西医结合]