血脂异常痰浊阻遏证汤剂用药规律  

Medication Rule of TCM Decoction in Treating Dyslipidemia with Phlegm Turbidity Repression Syndrome

作　　者：黄书婷[1,2] 张凤霞 杨雪松[3] 牟淑敏[3] 赵家军[2] HUANG Shu-ting;ZHANG Feng-xia;YANG Xue-song;MOU Shu-min;ZHAO Jia-jun(Shangdong University of TCM, Ji＇nan, Shangdong, China, 250014;Affiliated Hospital of Shandong University of TCM, Ji＇nan, Shandong, China, 250014;Affiliated Provincial Hospital of Shandong University, Ji＇nan, Shandong, China, 250021)

机构地区：[1]山东中医药大学,山东济南250014 [2]山东大学附属省立医院,山东济南250021 [3]山东中医药大学附属医院,山东济南250014

出　　处：《河南中医》2018年第5期789-797,共9页Henan Traditional Chinese Medicine

基　　金：国家中医药管理局全国名老中医药专家王新陆传承工作室项目;国家中医药管理局齐鲁内科时病流派传承工作室(编号:LP0115033);国家自然科学基金项目(编号:81573945)

摘　　要：目的:尝试以古籍性味归经为依据分析血脂异常痰浊阻遏证汤剂用药规律。方法:以万方期刊全文数据库、维普期刊全文数据库、CHKD中文全文数据库、中国生物医学文献服务系统(CBM)数据库中公开发表的文献为基础,运用SPSS22.0与IBM SPSS Modeler 14.1软件,通过频数统计、聚类分析、关联规则算法分析药物组成及用量。结果:(1)发现高频性味为寒、温,甘、苦,归经为肝、脾经。(2)得到9味高频药物,分别是泽泻、白术、丹参、山楂、茯苓、半夏、陈皮、黄芪、决明子,与既往研究结论较为一致。(3)得到潜在药物组合7对。结论:(1)在一定程度上证明甘温益气健脾,苦寒清热燥湿是目前血脂异常痰浊阻遏证的主流治疗方法。(2)痰饮形成可能不止包括水液代谢障碍,可能也涉及食物消化吸收利用排泄的异常。(3)本次数据挖掘支持从肝脾论治血脂异常的观点。(4)决明子、荷叶,山楂、决明子等组合或可作为代茶饮,用以防治血脂异常痰浊阻遏证。(5)泽泻、白术、丹参、山楂、茯苓、半夏、陈皮、黄芪、决明子为治疗血脂异常痰浊阻遏证的常用药物,其中泽泻、丹参、白术尤为常用。Objective： Based on medicinal properties and meridian tropism,in the ancient medical classics,we try to analyze the rule of TCM decoction for dyslipidemia with phlegm turbidity repression syndrome. Methods： Based on the documents published in the Wanfang periodical full text database,VP journal full text database,CHKD Chinese full text database and Chinese biomedical literature service system(CBM） database,SPSS 22 and IBM SPSS Modeler 14. 1 software were used to analyze drug groups and dosage by frequency statistics,clustering analysis and association rules algorithm. Results： 1. It was found that high frequency of medicinal properties was cold,warm,sweet and bitter,and meridian tropism included the liver and spleen meridian. 2.Nine high-frequency drugs were obtained,namely Zexie(Rhizoma Alismatis）,Baizhu(Rhizoma Atractylodis Macrocephalae）,Danshen(Radix et Rhizoma Salviae Miltiorrhizae）,Shanzha(Fructus Crataegi）,Fuling(Poria）,Banxia(Rhizoma Pinelliae）,Chenpi(Pericarpium Citri Reticulatae）,Huangqi(Radix Astragali）,Juemingzi(Semen Cassiae）,which was consistent with the previous research conclusions. 3. Seven pairs of potential drug combinations were obtained. Conclusion： 1. To some extent,it is proved that sweet and warm can replenish qi and strengthen the spleen,while bitter and cold can clear away heat and dry dampness,the mainstream for treating dyslipidemia with phlegm turbidity repression syndrome. 2. Phlegm formation may include more than disturbance of water metabolism,may also involve abnormal excretion of the digestion and absorption of food. 3. This data mining supports the viewpoint of treating abnormal lipid from regulating the liver and spleen. 4. Lotus leaf-Juemingzi,ShazhaJuemingzi and other combinations be used as a substitute for tea,for the prevention and treatment of dyslipidemia with phlegm turbidity repression syndrome. 5. Zexie(Rhizoma Alismatis）,Baizhu(Rhizoma Atractylodis Macrocephalae）,Danshen(Radix et Rhizoma Salviae Miltiorrhizae）,Shanzha(Fructus Crataeg

关 键 词：血脂异常 痰浊阻遏证 高脂血症 聚类分析 关联规则 用药规律 

分 类 号：R287[医药卫生—中药学]