三氮脒注射液在山羊体内的药动学比较  

The Comparison of Pharmacokinetics of Diminazene Aceturate Injection in Goats

作　　者：张超[1] 曾杨梅 姜波 吴俊伟[1,2] ZHANG Chao;ZENG Yang-mei;JIANG Bo;WU Jun-wei(Southwest University of Rongchang Campus, Chongqing 402460;Chongqing Bull Animal Pharmaceutical Co. Ltd.)

机构地区：[1]西南大学荣昌校区,重庆402460 [2]重庆布尔动物药业有限公司

出　　处：《畜牧兽医杂志》2018年第3期17-20,共4页Journal of Animal Science and Veterinary Medicine

基　　金：重庆市科学技术委员会"三氮脒注射液的研制和产业化"

摘　　要：研究新制剂三氮脒注射液在山羊体内的药动学特征。用三氮脒和三氮脒注射液给山羊单剂量(3.5mg·kg-1)肌内注射,采用高效液相色谱法测定山羊体内三氮脒含量,3P97软件拟合血药浓度-时间曲线,计算药动学参数。三氮脒和三氮脒注射液药动学参数符合一级吸收二室模型,主要药动学参数分别为:达峰浓度(Cmax)为(5.97±0.37)μg·mL-1和(7.63±0.41)μg·mL-1;达峰时间(Tmax)为(0.22±0.03)h和(0.40±0.10)h;吸收半衰期(t1/2ka)为(0.13±0.04)h和(0.04±0.01)h;药时曲线下面积(AUC)为(53.96±6.87)μg·mL-1*h和(77.43±6.71)μg·mL-1*h。三氮脒注射液与三氮脒相比,具有吸收缓慢、分布广、安全性好和作用时间长等特点,此结论为临床合理使用剂型提供依据和指导。In order to study the pharmacokinetics of the diminazene aceturate injection in goats.Single-dose（3.5 mg·kg-1）intramuscular injection of diminazene aceturate and diminazene aceturate injection in goat.The content of diminazene aceturate in goat was determined by HPLC,3 P97 software was used to acquire plasma concentration-time curve,pharmacokinetic parameters were calculated.The diminazene aceturate and diminazene aceturate injection were in accordance with the firstorder absorption of two-compartment model.The major pharmacokinetic parameters were：Cmax（5.97±0.37）μg·mL-1 and（7.63±0.41）μg·mL^-1;Tmax（0.22 ± 0.03）h and（0.40±0.10）h;t1/2 ka（0.13±0.04）h and（0.04±0.01）h;AUC（53.96±6.87）μg·mL^-1＊h and（77.43±6.71）μg·mL^-1＊h.Compared with diminazene aceturate,diminazene aceturate injection has the characteristics of slow absorption,wide distrbution,safety and long acting time.This conclusion provides basis and guidance for the rational use of dosage forms.

关 键 词：三氮脒 山羊 注射用三氮脒 药动学 

分 类 号：S859[农业科学—临床兽医学]