湖南地区成人血清IgG亚类水平调查及影响因素分析  

Investigation on serum IgG subclass concentrations in the adult population of Hunan region and their influencing factors

作　　者：罗昔波[1] 陈丽军 任亚萍[1] 胡敏[1] LUO Xibo;CHEN Lijun;REN Yaping;HU Min(Department of Clinical Laboratory, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan;Department of Clinical Laboratory, School of Medicine, Hunan Normal University, Changsha 410011, Hunan , China)

机构地区：[1]中南大学湘雅二医院检验科,长沙410011 [2]湖南师范大学医学院医学检验系,长沙410001

出　　处：《临床检验杂志》2018年第4期309-313,共5页Chinese Journal of Clinical Laboratory Science

摘　　要：目的调查湖南地区成年人血清IgG亚类的浓度水平,探讨年龄、性别及生活方式等因素的影响。方法用免疫散射比浊法测定170例体检者血清中IgG_1、IgG_2、IgG_3、IgG_4和IgG浓度。结果血清IgG_1、IgG_2、IgG_3、IgG_4和IgG浓度分别为(7.53±0.14)g/L、3.99(3.13,5.02)g/L、0.49(0.30,0.70)g/L、0.53(0.26,0.93)g/L、12.2(10.5,14.1)g/L;血清IgG_1/IgG、IgG_2/IgG、IgG_3/IgG和IgG_4/IgG分别为(61.3±0.69)%、33.38(27.8,38.8)%、3.97(2.5,5.3)%和4.44(2.1,7.3)%。女性血清IgG_3浓度及IgG_3/IgG比值高于男性(P=0.005,0.014);不同性别间IgG_1、IgG_2、IgG_4及IgG_1/IgG、IgG_2/IgG、IgG_4/IgG的差异无统计学意义。31~40岁组血清IgG_3浓度显著高于41~50岁组(P=0.03),而年龄对血清IgG_1、IgG_2和IgG_4浓度的影响无统计学意义。重度吸烟组血清IgG_1的浓度比不吸烟组低,差异有统计学意义(P=0.023)。重度吸烟组IgG_4/IgG高于不吸烟组(P=0.018)。中/重度饮酒组血IgG_1、IgG_3浓度和IgG_3/IgG比值比不饮酒组低(P=0.05,0.004,0.015)。代谢综合征低风险组血清IgG_3和IgG_3/IgG高于高风险组(P=0.034,0.038)。结论性别和年龄对于血清IgG_3浓度的影响有显著意义。重度吸烟可能导致IgG_1的浓度降低和IgG_4/IgG比值的上升。血清IgG_1、IgG_3和IgG_3/IgG的降低与饮酒存在一定的关系。Objective To investigate serum IgG subclass concentrations in the adult population of Hunan region, and the effects of age, gender and lifestyle on them. Methods Serum IgG1 , IgG2, IgG3 , IgG4 and IgG concentrations from 170 adults making a health examination were detected by the immunonephelometric assay. Results The concentrations (mean or median [ P25, P75 ]） of serum IgG1, IgG2, IgG3, IgG4 and IgG were （7.53 ±0.14） g/L, 3.99 （3.13, 5.02） g/L, 0.49 （0.30, 0.70） g/L, 0.53 （0.26, 0.93） g/L and 12.2 （10.5, 14.1) g/L, respectively. The serum IgG1/IgG, IgG2/IgG, IgG3/IgG and IgG4/IgG were （61.3 ±0.69）%, 33.38% （27.8%, 38.8%), 3.97% （2.5%, 5.3%) and 4.44% （2.1%, 7.3%), respectively. The serum IgG3 concentrations and IgG3/IgG ratios in female adults were significantly higher than that in male adults （P = 0. 005 and 0. 014）. However, there were no significant difference in serum IgG1 , IgG2 and IgG4 concentrations and IgG1/IgG, IgG2/IgG and IgG4/IgG ratios between male and female adults. The serum IgG3 concentrations in the 31-40 years old adults were significantly higher than that in the 41-50 years old (P = 0. 03) , while there were no significant difference in serum IgG1 , IgG2 and IgG4 concentrations between different age groups. The serum IgG1 concentrations in the adults with heavy smoking were significantly lower than that without smoking (P = 0. 023) , while the serum IgG4/IgG ratios were the opposite （P = 0. 018). The serum IgG1 and IgG3 concentrations and IgG3/IgG ratios in the adults with midrange or heavy drinking were significantly lower than that without ethanol consumption (P = 0.05, 0. 004 and 0. 015, respectively）. The serum IgG3 concentrations and IgG3/IgG ratios in the adults with low-risk metabolism syndrome were significantly higher than that with the high-risk (P = 0. 034 and 0. 038). Conclusion Gender and age have the significant effect on serum IgG3 concentration. Heavy smoking may reduce serum IgG1 concentration and increase IgGg/IgG ratio. The decrease

关 键 词：IGG1 IgG2 IGG3 IGG4 IGG亚类 成人 湖南地区 

分 类 号：R446.6[医药卫生—诊断学]