我国8省市一般人群尿中镓、铟、铊水平分布的研究  

Distribution of Urinary Gallium,Indium and Thallium of General Population in 8 Provinces of China

作　　者：张福钢 丁春光 潘亚娟[3] 闫慧芳[3] ZHANG Fugang1;DING Chunguang2;PAN Yajuan3;YAN Huifang3

机构地区：[1]中国疾病预防控制中心化学安全与健康重点实验室 [2]国家安监总局职业安全卫生研究中心 [3]中国疾病预防控制中心职业卫生与中毒控制所

出　　处：《环境卫生学杂志》2018年第2期86-90,98,共6页JOURNAL OF ENVIRONMENTAL HYGIENE

基　　金：卫生部行业科研专项项目:突发化学中毒事件第一现场处置关键技术研究(200802020);国家科技支撑计划项目:重金属和有机溶剂对工人健康损害的生物监测和预防控制研究(2006BAI06B02)

摘　　要：目的了解我国一般人群尿中镓、铟、铊水平,分析其人群分布特征。方法于2009—2010年,在我国东部、西部和中部8个省(市、自治区)的24个地区,采用分层整群随机抽样的方法抽取了18 120名(6~60)岁人群为研究对象,对其生活习惯和健康状况进行了问卷调查,并采集其尿液样品。应用电感耦合等离子体质谱法对尿样进行镓、铟、铊含量检测,统计分析性别、不同年龄人群尿中镓、铟、铊水平的分布。结果我国一般人群尿镓第50百分位数<LOD(0.08μg/L);第95百分位数为1.72μg/L;男性和女性尿镓第50百分位数均<LOD(0.08μg/L),男性和女性人群尿镓检出率分别为26.5%,21.6%(χ~2=43.478,P<0.01)。一般人群尿铟第50百分位数为<LOD(0.03μg/L),第95百分位数为0.61μg/L;男性和女性尿铟第50百分位数均为<LOD(0.03μg/L),男性和女性人群尿铟检出率分别为16.3%,18.1%(χ~2=5.234,P<0.05);一般人群尿铊几何均值为(0.17±0.01)μg/L,第50百分位数为0.27μg/L,第95百分位数为1.37μg/L。男性和女性尿铊几何均值分别为(0.18±0.01)μg/L、(0.16±0.01)μg/L(Z=4.86,P<0.01);男性和女性人群尿铊检出率分别为84.0%,83.0%(χ~2=2.577,P>0.05)。结论本研究报道了我国2009—2010年一般人群尿中镓、铟、铊的含量和分布水平,为进一步开展镓、铟、铊的生物监测等研究提供基础数据。Objectives To evaluate the urinary gallium(Ga）,indium(In） and thallium(Tl） level of general people in China and to analyze their population distribution.Methods A total of 18 120 subjects from general population aged 6-60 years were recruited from 24 districts in 8 provinces of eastern,central and western China from 2009 to 2010 by cluster random sampling method,and their urinary samples were collected.A questionnaire survey method was used to collect the information on their living environment and health condition.Inductively coupled plasma mass spectrometry(ICP-MS） was applied to determine Ga,In and Tl level in urine samples,and the distribution of urinary Ga,In and Tl in different ages and genders was then analyzed.Results In general,the 50-（th） percentiles of urinary Ga was 0.08 μg/L(LOD）,and the 95-（th） percentile was 1.72 μg/L.The 50-（th）percentile of urinary Indium in male and female were all 0.08 μg/L(LOD）.The detection rate of urinary Ga in male and female were 26.5% and 21.6% respectively(χ-2= 43.478,P〈0.01）,The 50-（th） percentile of urinary indium was0.03 μg/L(LOD）,and the 95 thpercentile was 0.61 μg/L.The 50-（th） percentile of urinary indium in males and females were all 0.03 μg/L(LOD）.The detection rate of urinary indium in male and female were 16.3% and 18.1%(χ-2= 5.234,P〈0.05） respectively.The geometric mean(GM） of urinary thallium was(0.17 ± 0.01） μg/L,the 50-（th） percentile was 0.27 μg/L and the 95-（th） percentile was 1.37 μg/L.The geometric mean(GM） of urinary Tl in male and female were(0.18 ± 0.01） μg/L and(0.16 ± 0.01） μg/L(Z = 4.86,P〈0.01）.The detection rate of urinary thallium were 84.0% and 83.0% for male and female(χ-2= 2.577,P〈0.05） respectively.Conclusions The concentrations and distribution of urinary gallium,indium and thallium in the general population in China reported in this study provided a basic data and evidence for further studies on biological monitoring gallium,indium and thallium in Chines

关 键 词：镓 铟 铊 尿 电感藕合等离子体质谱 横断面研究 

分 类 号：R113[医药卫生—公共卫生与预防医学]