不同剂量布地奈德混悬液氧气雾化吸入联合蛇胆陈皮口服液对婴幼儿喘息的疗效及发作对比研究  

Comparative study of efficacy and seizures of different doses of oxygen atomization inhalation of budesonide suspension combined with Shedan Chenpi oral liquid on infantile wheezing

作　　者：汤玉妍 廖友明 李碧燕 白翠芬 TANG Yu-yan;LIAO You-ming;LI Bi-yan;et al.(Foshan Nanhai District People＇ s Hospital, Foshan 528000, Chin)

机构地区：[1]佛山市南海区人民医院,528000

出　　处：《中国实用医药》2018年第14期7-9,共3页China Practical Medicine

摘　　要：目的对比研究不同剂量布地奈德混悬液氧气雾化吸入联合蛇胆陈皮口服液对婴幼儿喘息的疗效及发作改善情况。方法 140例婴幼儿喘息患儿,随机分为对照组和观察组,各70例。对照组给予低剂量布地奈德混悬液氧气雾化吸入联合蛇胆陈皮口服液治疗,观察组给予高剂量布地奈德混悬液氧气雾化吸入联合蛇胆陈皮口服液治疗。比较两组症状、体征等消失时间,治疗效果及不良反应。结果观察组气喘、胸闷、咳嗽、呼吸困难消失时间分别为(1.21±0.51)、(1.65±0.53)、(4.02±0.81)、(1.18±0.50)d均短于对照组的(1.54±0.57)、(2.02±0.67)、(4.59±0.88)、(1.56±0.55)d,差异有统计学意义(P<0.05)。观察组总有效率为100.00%,高于对照组的91.43%,差异有统计学意义(P<0.05)。两组不良反应发生率均为1.43%,比较差异无统计学意义(P>0.05)。结论高剂量布地奈德混悬液氧气雾化吸入联合蛇胆陈皮口服液治疗婴幼儿喘息的疗效显著,发作改善明显,具有重要临床价值。. Objective To comparative study the efficacy and seizures improvement of different doses of oxygen atomization inhalation of budesonide suspension combined with Shedan Chenpi oral liquid on infantile wheezing. Methods A total of 140 children with infantile wheezing were randomly divided into control group and observation group, with 70 cases in each group. The control group was treated with low-dose oxygen atomization inhalation of budesonide suspension combined with Shedan Chenpi oral liquid, and the observation group was treated with high-dose oxygen atomization inhalation of budesonide suspension combined with Shedan Chenpi oral liquid. Comparison were made on symptom and signs disappearance time, treatment effect and adverse reactions between the two groups. Results The observation group had shorter disappearance time of asthma, chest tightness, cough and dyspnea respectively as （1.21 ± 0.51）, （1.65 ± 0.53）, （4.02 ± 0.81） and （1.18 ± 0.50） d than （1.54 ± 0.57）, （2.02 ± 0.67）, （4.59 ± 0.88） and （1.56 ± 0.55） d in the control group, and their difference was statistically significant （P〈O.05）. The observation group had higher total effective rate as 100.00% than 91.43% in the control group, and the difference was statistically significant （P〈0.05）. Both groups had incidence of adverse reactions as 1.43%, and the difference was not statistically significant （P〉0.05）. Conclusion High-dose oxygen atomization inhalation of budesonide suspension combined with Shedan Chenpi oral liquid shows remarkable efficacy in treating infantile wheezing, and can obviously improve seizures, and it is of great clinical value.

关 键 词：婴幼儿喘息 布地奈德混悬液 蛇胆陈皮口服液 不同剂量 

分 类 号：R725.6[医药卫生—儿科]