原发免疫性血小板减少症患者血小板膜糖蛋白与中医证型的相关性研究  

Correlation between platelet membrane glycoprotein and TCM syndromes in the patients with immune thrombocytopenia

作　　者：张娜[1] 燕小宁 杨红蓉[1] 肖晶[1] 李新鹏[1] 王钊林[3] ZHANG Na;YAN Xiao - ning;YANG Hong - rong;XIAO Jing;LI Xin - peng;WANG Zhao - lin(Shanxi Chinese Medicine Hospital, Taiyuan Shanxi 030012;Shanxi University of Traditional Chinese Medicine, Taiyuan Shanxi 030619;Second Affiliated Hospital of Shanxi Medical University,Taiyuan Shanxi 030001)

机构地区：[1]山西省中医院,山西太原030012 [2]山西中医药大学,山西太原030619 [3]山西医科大学第二医院,山西太原030001

出　　处：《世界中西医结合杂志》2018年第4期517-520,共4页World Journal of Integrated Traditional and Western Medicine

基　　金：山西省中医药研究院院级课题(201501)

摘　　要：目的探讨原发免疫性血小板减少症(ITP)患者血小板膜糖蛋白(GP)与中医证型的相关性。方法选择血液科就诊的100例住院及门诊ITP患者,进行中医辨证分型,检测患者的血小板(PLT)计数,应用流式细胞术(FCM)检测GPⅡb/Ⅲa、GPⅠb/Ⅸ水平。结果 ITP患者以血热妄行证为主,PLT与GPⅡb/Ⅲa、GPⅠb/Ⅸ呈正相关。ITP患者不同中医证型的PLT水平存在差异,血热妄行型、阴虚血热型PLT水平低于气虚不摄型、瘀血内阻型,差异均有统计学意义(P<0.05)。不同中医证型ITP患者GPⅡb/Ⅲa、GPⅠb/Ⅸ表达有所不同,血热妄行型、气虚不摄型ITP患者GPⅡb/Ⅲa水平低于阴虚血热型、瘀血内阻型,差异均有统计学意义(P<0.05);血热妄行型ITP患者GPⅠb/Ⅸ水平低于阴虚血热型、气虚不摄型、瘀血内阻型,差异均有统计学意义(P<0.05)。结论 ITP患者以血热妄行证为主,不同中医证型ITP患者GPⅡb/Ⅲa、GPⅠb/Ⅸ表达有所不同。Objective To explore the correlation between platelet membrane glycoprotein(GP） and TCM syndromes in the patients with immune thrombocytopenia(ITP）. Methods A total of 100 ITP inpatients and outpatients visited in the hematology department were selected and differentiated with TCM theory. PLT was detected. GPⅡb/Ⅲa and GPⅠb/Ⅸ were determined with FCM. Results The excessive blood heat syndrome was predominated in ITP patients. PLT was positively related to GPⅡb/Ⅲa and GP Ⅰb/Ⅸ. PLT levels were different among different TCM syndromes of ITP.PLT levels for the excessive blood heat and yin deficiency and blood heat syndromes were lower than the syndromes as the failure of blood control due to qi deficiency and internal blockage with blood stasis,indicating the significant differences(P〈 0. 05）. The expressions of GPⅡb/Ⅲa and GP Ⅰb/Ⅸ were different among different TCM syndromes. GPⅡb/Ⅲa expression in syndromes as the excessive blood heat and the failure of blood control due to qi deficiency was lower than the syndromes as yin deficiency and blood heat,and internal blockage with blood stasis,indicating the significant differences(P〈 0. 05）. GP Ⅰ b/Ⅸ in the syndrome as the excessive blood heat was lower than the syndromes as yin deficiency and blood heat,the failure of blood control due to qi deficiency and internal blockage with blood stasis,indicating the significant differences(P〈 0. 05）. Conclusion The excessive blood heat is predominated in ITP patients. The expressions of GPⅡb/Ⅲa and GP Ⅰb/Ⅸ are different among different TCM syndromes of ITP.

关 键 词：原发免疫性血小板减少症 血小板膜糖蛋白 中医证型 血小板 

分 类 号：R558[医药卫生—血液循环系统疾病]