菖郁二黄汤治疗重度颅脑损伤的疗效观察  

Clinical therapeutic effects of changyu erhuang decoction on severe craniocerebral injury( phlegm and heat stagnation)

作　　者：孙滢[1] 刘景 王知兵 王健[1] 周晓燕[1] 魏丽丽[1] SUN Ying;LIU Jing;WANG Zhi - bing;WANG Jian;ZHOU Xiao - yan;WEI Li - li(Hebei Cangzhou Hospital of Integrated Chinese and Western Medicine, Cangzhou Hebei 061000)

机构地区：[1]河北省沧州中西医结合医院,河北沧州061000

出　　处：《世界中西医结合杂志》2018年第4期539-542,546,共5页World Journal of Integrated Traditional and Western Medicine

摘　　要：目的观察菖郁二黄汤对重度颅脑损伤患者的临床效果。方法选择2014年3月至2016年3月于河北省沧州中西医结合医院重症医学科诊治的重度颅脑损伤患者60例,辨证分型为痰瘀热结证。采用随机对照方法分为对照组和治疗组,各30例。对照组给予西医标准治疗,治疗组在对照组基础上加用菖郁二黄汤。两组治疗7 d后观察格拉斯哥评分(GCS)评分、昏迷程度、并发症及预后疗效情况。结果两组患者入院时,入院第1、2、3、4天时GCS评分比较差异无统计学差异(P>0.05);而第5、6、7天时两组评分比较,差异有统计学意义(P<0.05)。两组患者治疗后昏迷程度、并发症情况,治疗组改善程度明显优于对照组(P<0.05)。两组治疗后预后情况比较差异无统计学意义(P>0.05)。结论在西医标准治疗基础上加用菖郁二黄汤,可改善痰瘀热结证重度颅脑损伤患者GCS评分、昏迷程度、并发症等,说明菖郁二黄汤具有促醒、脑保护、减少颅脑损伤后并发症的作用,但在改善预后方面,治疗组与对照组疗效相当。Objective To observe the clinical effects of changyu erhuang decoction on severe craniocerebral injury(phlegm and heat stagnation）. Methods A total of 60 patients treated in the Intensive Care Unit of Beibei Cangzhou Hospital of Integrated Chinese and Western Medicine were collected from March 2014 to March 2016. According to the random control method,they were divided into a control group and a treatment group,30 cases in each one. In the control group,the routine western medicine was given. In the treatment group,on the base of the treatment as the control group,changyu erhuang decoction was added. In 7 days of treatment,GCS score,coma,complications and prognosis were observed.Results Separately,on the day of admission,on the 1 st,2 nd,3 rdand 4 thdays after admission,the differences were not significant in GCS score between the two groups(P〉 0. 05）. But the differences were significant on the 5 th,6 thand 7 thdays(P 〈 0. 05）. The improvements in coma severity and complications after treatment in the treatment group were better obviously than the control group(P 〈 0. 05）. Regarding the prognosis,the differences were not significant between the two groups(P 〈 0. 05）. Conclusion On the base of routine western medicine treatment,changyu erhuang decoction improves in GCS score,coma severity and complications in the patients of severe craniocerebral injury. It is explained that changyu erhuang decoction promotes the consciousness regaining and the brain protection and reduces the complications after craniocerebral injury. Regarding the prognosis,the effects are similar between the treatment group and the control group.

关 键 词：重度颅脑损伤 菖郁二黄汤 痰瘀热结证 

分 类 号：R651.1[医药卫生—外科学]