ICP-MS法测定酒石酸长春瑞滨中有害元素及催化剂银残留  

Measurement of the Residues of Harmful Elements and Silver Catalyst in Vinorelbine Tartrate by ICP-MS

作　　者：谢浙裕 朱琳娇 章少勇 Xie Zheyu;Zhu Linjiao;Zhang Shaoyong(Shaoxing Institute for Food and Drug Control, Shaoxing 312071, China;Minsheng Group Shaoxing Pharmaceutical Co. Ltd., Shaoxing 312000, China)

机构地区：[1]绍兴市食品药品检验研究院,绍兴312071 [2]绍兴民生医药有限公司,绍兴312000

出　　处：《中国药事》2018年第5期642-646,共5页Chinese Pharmaceutical Affairs

摘　　要：目的:建立电感耦合等离子体质谱法测定酒石酸长春瑞滨中有害元素及催化剂银残留的方法。方法:用微波消解处理样品,电感耦合等离子体质谱内标法测定银、钒、铬、钴、镍、铜、砷、钼、镉、锡、锑、钡、铅、汞的含量。结果:上述14种元素的方法检出限分别为0.003、0.020、0.141、0.069、0.077、0.362、0.031、0.057、0.022、0.078、0.017、0.724、0.095、0.005 ng·m L-1,线性关系良好(r≥0.9988),回收率为86%~110%,RSD小于15%;同时,给出了此方法各元素的不确定度评定程序。结论:本方法采用在线加内标,可有效校正仪器漂移,抑制基体干扰,提高准确率,多元素测定便捷、准确、灵敏、可靠,可用于酒石酸长春瑞滨中有害元素及催化剂银残留的测定。Objective： To establish a method for the measurement of the residues of harmful elements and silver catalyst in Vinorelbine Tartrate by inductively coupled plasma-mass spectrometry（ICP-MS）. Methods： The samples were dissolved by microwave digestion and Ag, V, Cr, Co, Ni, Cu, As, Mo, Cd, Sn, Sb, Ba, Pb, Hg were determined by ICP-MS with internal standard method. Results： The detection limit of the above mentioned 14 elements was 0.003, 0.020, 0.141, 0.069, 0.077, 0.362, 0.031, 0.057, 0.022, 0.078, 0.017, 0.724, 0.095, 0.005 ng·m L^-1, respectively. The results of the 14 elements showed good linearity（r≥0.9988）. The recovery rates were 86% to 110% and the relative standard deviations（RSDs） were less than 15%. Furthermore, an evaluation program for uncertainty assessment was put forward. Conclusion： The method which uses online internal standard can effectively correct instrument drift, suppress matrix interference and improve accuracy, which is convenient, accurate, sensitive and reliable and can be used to measure the residue of harmful elements and silver catalyst in Vinorelbine Tartrate.

关 键 词：酒石酸长春瑞滨 有害元素 催化剂残留 电感耦合等离子体质谱法 不确定度 银 钒 铬 钴 镍 铜 砷 钼 镉 锡 锑 钡 铅 汞 

分 类 号：R927.11[医药卫生—药学]