川芎嗪早期干预动静脉内瘘成形术后随机平行对照研究  

A Randomized Parallel Controlled Study of Ligustrazine(川芎嗪) in the Early Intervention of Arteriovenous Fistula Plasty

作　　者：蒋背乐 熊有明[1] 韦小双 赵凤毛 JIANG Beile;XIONG Youming;WEI Xiaoshuang;ZHAO Fengmao(Internal Medicine Department Of Guilin TCM Hospital,Guilin 541002,Guangxi,China)

机构地区：[1]广西桂林市中医医院内科,广西桂林541002

出　　处：《实用中医内科杂志》2018年第4期16-18,77,共4页Journal of Practical Traditional Chinese Internal Medicine

摘　　要：[目的]观察川芎嗪早期干预动静脉内瘘成形术后疗效。[方法]使用随机平行对照方法,将100例住院患者按床位单双号顺序随机分为两组。对照组50例阿司匹林,1~3片/d。治疗组50例川芎嗪40~80mg+0.9%氯化钠500mL,1次/d,静滴。连续治疗20d为1疗程。观测临床症状、首次血液透析血流量、凝血指标、C反应蛋白、不良反应。疗1疗程(20d),随访1个月,判定疗效。[结果]血流量>200mL/min治疗组多于对照组(P<0.05)。相关凝血指标水平、C反应蛋白两组均有改善(P<0.05),治疗组改善优于对照组(P<0.05)。[结论]观察川芎嗪早期干预动静脉内瘘成形术后,疗效满意,无严重不良反应,值得推广。[[Objective] To observe the efficacy of early intervention of ligustrazine; pyrazine, tetramethyl after the arteriovenous fistula plasty. [Methods] According to the randomized parallel contrast study, 100 inpatients were randomly assigned to two groups according to the odd or even hospital bed number, 50 cases each group. The control group took 1～3 aspirin tablets everyday; the treatment group took the intravenousdrip with 40～80 mg of tetramethylpyrazine; pyrazine, tetramethyl plus 500 mL of 0.9% sodium chloride for once everyday, 20d a treatment course. The clinical symptoms, blood flow volume of initial hemodialysis, coagulation indicator, C-reactive protein and adverse reactions were recorded. After a treatment course and 1 m of followup visit, the efficacy was evaluated. [Results] The patients with blood flow volume〉200 mL/min in the treatment group were more than control group（P〈0.05）; the related coagulation indicators and C-reactive protein for two groups were improved（P〈0.05）; the above index in the treatment group were significantly better than control group（P〈0.05）. [Conclusion] After the arteriovenous fistula plasty, the early intervention of 2,3,5,6-tetramethylpyrazine; Pyrazine, tetramethyl have a favorable efficacy. In addition, there are no severe adverse reactions.

关 键 词：静脉内瘘成形术 川芎嗪 阿司匹林 早期干预 首次血液透析血流量 红细胞比积 血浆纤维蛋白 原血浆凝血酶时间 活化凝血活酶时间 C反应蛋白 中医药治疗 随机平行对照研究 

分 类 号：R277.5[医药卫生—中医学]