妊娠期糖尿病患者血浆超敏C-反应蛋白、糖化白蛋白与产后代谢综合征的关系研究  

Study on the relationships between plasma hypersensitivity C-reactive protein,glycated albumin and postpartum metabolic syndrome in patients with gestational diabetes mellitus

作　　者：姚叶娜 刘海燕 YAO Ye-Na;LIU Hai-Yan(Zhuji Central Hospital, Zhuji, Zhejiang 311809, China)

机构地区：[1]诸暨市中心医院,浙江诸暨311809 [2]浙江省中医药研究院,浙江诸暨310000

出　　处：《中国妇幼保健》2018年第10期2186-2189,共4页Maternal and Child Health Care of China

基　　金：浙江省科技计划项目(2014C33208)

摘　　要：目的分析妊娠期糖尿病(GDM)血浆超敏C-反应蛋白(hs-CRP)、糖化白蛋白(GA)与产后代谢综合征(MS)的关系。方法选取2012年4月-2014年8月在该院进行规律产检并分娩的100例GDM患者作为GDM组,另抽取同期100例健康孕妇作为健康组。对比两组hs-CRP、GA水平,再将GDM组按照2年内有无发生MS分为MS组与非MS组,对比hs-CRP、GA水平,将hs-CRP和GA水平分别与MS的其他危险因素进行Pearson相关性分析,再将hs-CRP和GA水平与MS进行Logistic分析。结果 GDM组血浆hs-CRP、GA、体质量指数(BMI)、收缩压(SBP)、空腹血糖(FPG)和三酰甘油(TG)水平均高于健康组(t=24.592、28.486、9.631、15.737、19.918、9.259,均P<0.05)。健康组产后2年患MS的比例为5.21%,低于GDM组的20.00%,差异有统计学意义(χ2=9.509,P<0.05)。MS组血浆hs-CRP、GA、BMI、SBP、FPG及TG水平均高于非MS组(t=9.887、10.430、14.452、10.284、12.126、16.905,均P<0.05)。hs-CRP和GA水平均与BMI、SBP、FPG、TG水平呈正相关(P<0.05)。hs-CRP和GA水平均为MS的独立危险因素。结论 GDM患者血浆hs-CRP和GA水平均升高,两个指标的升高与产后MS关系密切。Objective To analyze the relationships between plasma hypersensitivity C-reactive protein（hs-CRP）,glycated albumin（GA） and postpartum metabolic syndrome（MS） in patients with gestational diabetes mellitus（GDM）. Methods From April 2012 to August 2014,100 patients with GDM receiving regular prenatal examination and giving birth to their babies in Zhuji Central Hospital were selected as GDM group,and 100 healthy pregnant women during the same period were selected as healthy group. The levels of hs-CRP and GA in the two groups were compared. The patients in GDM group were divided into MS group and non-MS group according to complicating MS or not within two years,then the levels of hs-CRP and GA in the two groups were compared. The levels of hs-CRP and GA,and other risk factors of MS were analyzed by Pearson correlation analysis. The levels of hs-CRP and GA,and MS were analyzed by Logistic model.Results The levels of plasma hs-CRP,GA,body mass index（BMI）,systolic pressure（SBP）,fasting blood glucose（FPG）,and triglyceride（TG） in GDM group were statistically significantly higher than those in healthy group（t = 24. 592,28. 486,9. 631,15. 737,19. 918,9. 259,all P〈0. 05）. The incidence rate of MS within two years after delivery in healthy group was 5. 21%,which was statistically significantly lower than that in GDM group（20. 00%）（χ2= 9. 509,P〈0. 05）. The levels of plasma hs-CRP,GA,BMI,SBP,FPG,and TG in MS group were statistically significantly higher than those in non-MS group（t = 9. 887,10. 430,14. 452,10. 284,12. 126,16. 905,all P〈0. 05）. The levels of hs-CRP and GA were positively correlated with the levels of BMI,SBP,FPG,and TG（P〈0. 05）. The levels of hs-CRP and GA were independent risk factors of MS. Conclusion The levels of hs-CRP and GA elevate in patients with GDM,which are closely related to postpartum MS.

关 键 词：妊娠期糖尿病 超敏C-反应蛋白 糖化白蛋白 产后代谢综合征 

分 类 号：R714.25[医药卫生—妇产科学]