酚妥拉明及多巴胺治疗小儿高原性心脏病合并肺动脉高压的疗效  

Curative effect of phentolamine and dopamine in treatment of high altitude heart disease complicated with pulmonary arterial hypertension in children

作　　者：王顺琴 夏成[1] 刘勤 WANG Shun-Qin;XIA Cheng;LIU Qin.(Department of Pediatrics, People＇s Hospital of Ganzi Tibetan Autonomous Prefecture, Kangding, Sichuan 626000, Chin)

机构地区：[1]甘孜藏族自治州人民医院儿科,四川康定626000

出　　处：《中国妇幼保健》2018年第10期2259-2261,共3页Maternal and Child Health Care of China

摘　　要：目的探讨酚妥拉明及多巴胺治疗小儿高原性心脏病合并肺动脉高压的疗效,为临床治疗提供参考。方法选取2014年3月-2016年9月甘孜藏族自治州人民医院收治的190例高原性心脏病合并肺动脉高压患儿,随机分为两组,每组95例。所有患儿均给予常规综合治疗,观察组在此基础上给予酚妥拉明和多巴胺治疗。比较两组患儿的疗效及治疗前后的心率、心功能指标、动脉血气指标。结果两组患儿总有效率比较差异有统计学意义(P<0.05)。观察组和对照组患儿主要症状、体征改善时间分别为(4.30±1.00)d和(9.10±1.00)d,差异有统计学意义(P<0.05)。在两组中,患儿治疗前后的心率、肺动脉收缩压、右心室内径、右心室前壁厚度、左心室射血分数、右心室射血分数、动脉血氧分压(PaO_2)、动脉血二氧化碳分压(PaCO_2)、血氧饱和度(SaO_2)比较差异均有统计学意义(均P<0.05)。结论酚妥拉明及多巴胺治疗小儿高原性心脏病合并肺动脉高压的疗效确切。Objective To explore the curative effect of phentolamine and dopamine in treatment of high altitude heart disease complicated with pulmonary arterial hypertension in children,provide a reference for clinical treatment. Methods From March 2014 to September2016,190 children with high altitude heart disease complicated with pulmonary arterial hypertension were selected from People＇s Hospital of Ganzi Tibetan Autonomous Prefecture and randomly divided into two groups,95 children in each group. The children in control group were treated by routine comprehensive therapy,while the children in observation group were treated by routine comprehensive therapy and phentolamine,dopamine. The curative effects,heart rates,cardiac function indexes,arterial blood gas indexes before and after treatment in the two groups were compared. Result There was statistically significant difference in the total effective rate between the two groups(P〈0. 05）.The improvement time of main symptoms and signs in observation group and control group were(4. 30±1. 00） days and(9. 10±1. 00） days,respectively,there was statistically significant difference between the two groups(P〈0. 05）. In the two groups,there were statistically significant differences in heart rate,pulmonary arterial systolic pressure,right ventricular internal dimension,anterior wall thickness of right ventricle,left ventricular ejection fraction,right ventricular ejection fraction,arterial oxygen partial pressure(PaO2）,arterial partial pressure of carbon dioxide(PaCO2）,and oxyhemoglobin saturation(SaO2） between before and after treatment(P〈0. 05）. Conclusion The curative effect of phentolamine and dopamine in treatment of high altitude heart disease complicated with pulmonary arterial hypertension in children is good.

关 键 词：酚妥拉明 多巴胺 儿童 高原性心脏病 肺动脉高压 疗效 

分 类 号：R725.4[医药卫生—儿科]