不同疗程抑那通辅助腹腔镜治疗子宫内膜异位症的疗效及其对患者再孕和生活质量的影响·适宜技术·  

Curative effect of different courses of leuprorelin and laparoscopy in treatment of endometriosis and the impact on subsequent pregnancy and quality of life

作　　者：徐蓓蕾 XU Bei-Lei.(Department of Gynecology and Obstetrics, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang 310007, China)

机构地区：[1]杭州市中医院妇产科,浙江杭州310007

出　　处：《中国妇幼保健》2018年第10期2356-2359,共4页Maternal and Child Health Care of China

基　　金：浙江省自然科学基金(Y2110181)

摘　　要：目的探讨不同疗程抑那通辅助腹腔镜治疗子宫内膜异位症(EMs)的疗效及其对患者再孕和生活质量的影响,为EMs的治疗提供理论依据。方法选取2013年6月-2015年7月在杭州市中医院就诊的180例EMs患者为研究对象,对其临床资料进行回顾性分析,并根据是否应用抑那通和不同疗程分为A组(单纯腹腔镜手术治疗)、B组(1个疗程抑那通辅助腹腔镜手术治疗)和C组(2个疗程抑那通辅助腹腔镜手术治疗),每组各60例。比较3组患者的治疗疗效、生活质量评分、不良反应发生情况及随访2年的疼痛复发率、包块复发率、再自然妊娠率。结果 B、C组的治疗总有效率均明显高于A组(P<0.05),B组与C组治疗总有效率比较差异无统计学意义(P>0.05)。B组、C组疼痛复发率、包块复发率均低于A组(均P<0.05),C组疼痛复发率、包块复发率均低于B组(均P<0.05),B组、C组再自然妊娠率均高于A组(均P<0.05),B组与C组再自然妊娠率比较差异无统计学意义(P>0.05)。B组、C组生理、心理、环境、社会关系各维度评分及生活质量总评分均高于A组(P<0.05),C组生理、心理、环境、社会关系各维度评分及生活质量总评分高于B组(P<0.05)。3组患者不良反应总发生率比较差异无统计学意义(均P<0.05)。结论抑那通辅助腹腔镜治疗EMs临床疗效显著,可有效降低复发率,提高妊娠率及生活质量,且多疗程的抑那通辅助治疗对于降低复发率、提高生活质量效果更明显。Objective To explore the curative effect of different courses of leuprorelin and laparoscopy in treatment of endometriosis and the impact on subsequent pregnancy and quality of life,provide a theoretical basis for treatment of endometriosis. Methods From June2013 to July 2015,180 patients with endometriosis were selected from Hangzhou Hospital of Traditional Chinese Medicine,then the clinical data was analyzed retrospectively. The patients were divided into group A（simple laparoscopic surgery）,group B（one course of leuprorelin and laparoscopic surgery）,and group C（two courses of leuprorelin and laparoscopic surgery）,60 patients in each group. The curative effects,scores of life quality,incidence rates of adverse reactions,recurrence rates of pain and masses,subsequent natural pregnancy rates during follow-up of two years in the three groups were compared. Results The total effective rates in group B and group C were statistically significantly higher than that in group A（P〈0. 05）,there was no statistically significant difference in the total effective rate between group B and group C（P〈0. 05）. The recurrence rates of pain and masses in group B and group C were statistically significantly lower than those in group A（P〈0. 05）. The recurrence rates of pain and masses in group C were statistically significantly lower than those in group B（P〈0. 05）. The subsequent natural pregnancy rates in group B and group C were statistically significantly higher than those in group A（P〈0. 05）. There was no statistically significant difference in the subsequent natural pregnancy rate between group B and group C（P〈0. 05）.The scores of physiology,psychology,environment,and social relationship,the total scores of life quality in group B and group C were statistically significantly higher than those in group A（P〈0. 05）. The scores of physiology,psychology,environment,and social relationship,the total scores of life quality in group C were statistically significantly higher than thos

关 键 词：抑那通 腹腔镜 子宫内膜异位症 疗效 再孕 生活质量 

分 类 号：R711.74[医药卫生—妇产科学]