替加环素临床研究现状的分析  

Analysis of clinical research in the subject of tigecycline

作　　者：梅和坤[1] 王瑾[1] 柴栋[2] 王睿[1] 蔡芸[1] 梁蓓蓓[1] 唐铭婧[1] 罗鸣宇 MEI He - kun;WANG Jin;CHAI Dong;WANG Rui;CAI Yun;LIANG Bei - bei;TANG Ming - jing;LUO Ming - yu(a. Center of Medicine Clinical Research;b. Clinical Pharmacy Center, Chinese People＇s Liberation Army General Hospital, Beijing 100853, Chin;Z College of Pharmacy, Chongqing Medical University, Chongqing 400016, Chin)

机构地区：[1]解放军总医院药物临床研究中心,北京100853 [2]解放军总医院临床药学中心,北京100853 [3]重庆医科大学药学院,重庆400016

出　　处：《中国临床药理学杂志》2018年第10期1236-1239,共4页The Chinese Journal of Clinical Pharmacology

基　　金：中国人民解放军总医院临床扶持基金资助项目(2016FC-TSYS-2043)

摘　　要：目的分析替加环素的临床应用情况及研究现状。方法检索中国知网、Pub Med和EMbase数据库中替加环素的相关文献,截至2017年10月。用Endnote X7软件进行分类整理,对文献的发表年份和研究热点等进行分析。结果共纳入相关文献749篇,其中外文文献573篇,中文文献176篇。发文量最多的国家是美国(246篇,占32.8%)。目前的研究热点主要集中在超剂量用药、超适应证用药、药物不良反应和联合用药等。结论替加环素超剂量和超适应证具有一定的合理性。Objective To analyze the clinical application and latest progress of tigecycline. Methods All literatures were collected from CNKI,Pub Med and EMbase from the inception to October 2017. Bibliometric analysis was performed by Endnote X7 to analyze the published years and research hotspots. Results A total of 749 papers were analyzed,176 in Chinese and 573 in other languages. The United States ranked first(246 papers,taking up 32. 8%） in publishing articles among all the countries. At present,the research mainly focuses on overdose,over adaptation,adverse effects and combination therapy. Conclusion Overdose and over adaptation use of tigecycline have a certain rationality.

关 键 词：替加环素 计量分析 临床研究 超剂量使用 

分 类 号：R978.1[医药卫生—药品]