剪切波弹性成像弹性模量间接评估干燥综合征患者腮腺功能  

Shear wave elastography indirect evaluation on parotid gland function of Sjogren syndrome patients

作　　者：刘志兴[1] 陈莉[1] 王婧玲 吴锐[2] 陈璐[1] 赖珍珍 LIU Zhixing;CHEN Li;WANG Jingling;WU Rui;CHEN Lu;LAI Zhenzhen(Department of Ultrasound;Department of Rheumatology , the First Affiliated Hospital of Nanchang University, Nanchang 330006, China)

机构地区：[1]南昌大学第一附属医院超声诊断科,江西南昌330006 [2]南昌大学第一附属医院风湿免疫科,江西南昌330006

出　　处：《中国医学影像技术》2018年第5期664-667,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨剪切波弹性成像技术间接评估干燥综合征(SS)患者腮腺功能的价值。方法根据核素动态显像成像结果将100例SS患者分为腮腺功能正常组、轻度受损组、中度受损组及重度受损组,行剪切波弹性成像检查,获得腮腺杨氏模量值,比较4组间杨氏模量值的差异,并分析与腮腺功能的相关性,绘制ROC曲线,评价杨氏模量值诊断腮腺功能重度受损的效能。结果 4组间腮腺杨氏模量值差异有统计学意义(F=78.60,P<0.001)。腮腺杨氏模量值随腮腺功能受损程度加重而增高(r_s=0.83,P<0.001)。以38.38kPa为临界值,杨氏模量值诊断腮腺功能重度受损的曲线下面积为0.93(P<0.001),敏感度及特异度分别为89.3%及84.7%。结论剪切波弹性成像技术测量的弹性模量值可间接评估SS患者腮腺功能,为临床判断及随访SS病情变化提供依据。Objective To investigate the value of shear wave elastography（SWE）indirect evaluation on parotid function in Sjogren syndrome（SS）patients.Methods According to parotid function evaluated with scintigraphy,100 SS patients were divided into normal group,mild group,moderate group or severe group.SWE was performed in all the patients,and Young＇s modulus of parotid gland was obtained.The difference of Young＇s modulus among the four groups were compared,and the correlation between Young＇s modulus and paratid gland function were analyzed.ROC curve was used to evaluate the efficacy of Young＇s modulus in diagnosis of severe parotid function damage.Results The difference of Young＇s modulus among four groups was statistically significant（F=78.60,P〈0.001）.Young＇s modulus increased with the damage severity of parotid function（r_s=0.83,P〈0.001）.Taking 38.38 kPa as threshold,the area under ROC curve of Young＇s modulus was 0.93（P〈0.001）in diagnosis of severe parotid function damage and the sensitivity and specificity was 89.3% and 84.7%,respectively.Conclusion SWE can indirect evaluate parotid function in SS patients,and is valuable in diagnosis and long-term follow-up of SS.

关 键 词：超声检查 剪切波弹性成像 干燥综合征 腮腺 

分 类 号：R593.2[医药卫生—内科学] R445.1[医药卫生—临床医学]