我国队列人群1998～2015年血清总胆固醇水平的变化趋势  

Trends in Serum Total Cholesterol During 1998 to 2015 Among the Population-based Cohorts of China

作　　者：何伟林 陈纪春[1] 李莹[1] 黄建凤[1] 李建新[1] 赵连成[2] 曹杰[1] 刘小清[3] 杨学礼[1] 邓颖[4] 俞玲[5] 杨睿海 顾东风[1] HE Wei-lin;CHEN Ji-chun;LI Ying;HUANG Jian-feng;LI Jian-xin;ZHAO Lian-cheng;CAO Jie;LIU Xiao-qing;YANG Xue-li;DENG Ying;YU Ling;YANG Rui-hai;GU Dong-feng.(Department of Epidemiology, National Center for Cardiovascular Diseases and Fuwai Hospital, CAMS and PUMC, Beijing （100037）, China)

机构地区：[1]中国医学科学院北京协和医学院国家心血管病中心阜外医院流行病研究部,北京市100037 [2]中国医学科学院北京协和医学院国家心血管病中心阜外医院防治网络部,北京市100037 [3]广东省心血管病研究所 [4]四川省疾病预防控制中心 [5]福建省立医院心内科 [6]陕西省汉中市心血管病研究所

出　　处：《中国循环杂志》2018年第5期452-456,共5页Chinese Circulation Journal

基　　金："十三五"国家重点研发计划(2017YFC0211703);中国医学科学院医学与健康科技创新工程(2017-I2M-1-004;2016-I2M-3-018);"十二五"国家科技支撑计划(2011BAIll B03;2011BAl09B03)

摘　　要：目的:探讨我国队列人群1998~2015年血清总胆固醇(TC)水平的变化趋势。方法:研究对象来自中国心血管病流行病学多中心协作研究(ChinaMUCA)和心血管健康多中心合作研究(InterASIA)的队列人群。两项研究的队列人群以1998~2001年心血管病危险因素调查为基线,此后在2007~2008年和2013~2015年又进行了两次随访。本次分析纳入了三次调查中血清TC信息完整的35~74岁的9 477例研究对象。采用重复测量设计资料方差分析法比较不同人群血清TC的变化,人群血清TC水平采用均数(标准误)表示。结果:本研究队列人群三次调查的血清TC水平呈升高趋势:基线水平为4.81(0.01)mmol/L,后两次调查分别为4.91(0.01)mmol/L和4.98(0.01)mmol/L,增长率依次为2.08%和3.53%(P_(trend)<0.001)。女性人群血清TC水平上升,且35~45岁青年女性增长幅度最大(11.43%),男性人群血清TC水平变化不显著。城市人群血清TC水平始终高于农村人群且增速更快。结论:1998~2015年我国队列人群血清TC水平增高,其中青年女性和城市人群增幅较大,是心血管病防治的重点关注人群。Objectives： To explore the trends of serum total cholesterol（TC） among Chinese adult cohorts from 1998 to 2015. Methods： The subjects of this study came from China Multicenter Collaborative Study of Cardiovascular Epidemiology and International Collaborative Study of Cardiovascular Disease in Asia. The baseline investigations were completed during 1998-2001, and the two follow-ups were conducted during 2007-2008 and 2013-2015, respectively. A total of 9 477 participants aged 35-74 years with complete serum TC data from three surveys were included in this study. Analysis on variance of data regarding repeated measurements were used to investigate the variation of serum TC in different subgroups. The serum TC levels were represented by mean（standard errors）. Results： During 1998-2015, the mean level of serum TC of all participants significantly elevated from 4.81（0.01） mmol/L to 4.91（0.01） mmol/L, and to 4.98（0.01） mmol/L, growth rates of which were 2.08% and 3.53% in the first and second follow-up, respectively（Ptrend 0.001）, especially for females. The fastest growth was noted in the group of young women aged 35-45 years over time, with a growth rate of 11.43%. No such a significant change in the male group during follow-up. The serum TC level and itsgrowth rate in urban residents was significantly higher than those in rural residents. Conclusions： Longitudinal data demonstrated that the mean serum TC level among Chinese adults was continuously increased during 1998-2015. Prevention strategy for hypercholesterolemia should focus more on young women and urban residents.

关 键 词：血清总胆固醇 前瞻性 队列研究 随访 

分 类 号：R541[医药卫生—心血管疾病]