细辛脑注射液联合支气管肺泡灌洗术治疗儿童难治性支原体肺炎疗效观察  

The efficacy of asarone injection combined with bronchoalveolar lavage for refractory Mycoplasma pneumonia in Children

作　　者：王清清 苏卫东 张微微 蓝引乐[2] WANG Qing-qing;SU Wei-dong;ZHANG Wei-wei(Department of Pediatrics, Wenzhou Children＇s Hospital~Integrated Traditional Chinese and Western Medicine Hospital, Wenzhou, Zhejiang 325000, Chin)

机构地区：[1]温州市儿童医院/中西医结合医院儿科,浙江温州325000 [2]浙江大学医学院附属儿童医院呼吸科,浙江杭州310052

出　　处：《中华全科医学》2018年第7期1137-1140,共4页Chinese Journal of General Practice

基　　金：浙江省医药卫生研究计划(2012KYA120)

摘　　要：目的探讨细辛脑注射液联合支气管肺泡灌洗术治疗儿童难治性支原体肺炎(RMPP)的临床疗效,期望为该疾病的优化治疗提供一定的借鉴。方法将2015年1月—2016年1月温州市儿童医院收治的86例RMPP患儿使用随机数字表法平均分为观察组与对照组。所有患儿均给予抗感染、平喘等常规治疗,对照组在常规治疗的基础上另给予支气管肺泡灌洗术治疗,观察组在对照组治疗基础上同时给予细辛脑注射液进行治疗。治疗后,观察2组患儿的临床疗效。治疗前后,分别检测2组患儿血氧分压(Pa O2)、二氧化碳分压(PaCO_2)及p H等血气指标水平。治疗期间,观察2组患儿肺部阴影、高热、咳嗽及肺部啰音等症状的缓解时间。治疗前后,分别抽取各组患儿静脉血,检测C反应蛋白(CRP)、红细胞沉降率(ESR)及中性粒细胞分类水平。观察患儿并发症及不良反应的发生情况。结果观察组的总有效率为90.7%,明显高于对照组69.8%(P<0.05);治疗后,观察组Pa O2及p H分别为(73.64±7.74)mm Hg(1 mm Hg=0.133 k Pa)及7.35±0.15,均明显高于对照组(均P<0.05),而PaCO_2、CRP、ESR及中性粒细胞分类水平分别为(49.45±6.78)mm Hg、(23.38±3.36)mg/L、(32.87±4.62)mm/1 h及(43.62±6.72)%,均明显低于对照组(均P<0.05);观察组患儿肺部阴影、高热、咳嗽及肺部啰音等症状的缓解时间均明显短于对照组(均P<0.05)。治疗期间所有患儿均未出现严重并发症及不良反应。结论细辛脑注射液联合支气管肺泡灌洗术治疗RMPP临床疗效较好,值得开展深入研究。Objective To explore the efficacy of asarone injection combined with bronchoalveolar lavage for refractory myeoplasma pneumonia （RMPP） in children, thus to provide reference for optimizing treatment. Methods A total of 86 cases of RMPP children from January, 2015 to January, 2016 in our hospital were divided into the control group （ n =43 ） and the treatment group （n = 43 ） by a randomized way. The children were given regular treatments including anti-infec- tion and spasmolysis. The control group was given bronehoalveolar lavage , the treatment group was given asarone injection on the basis of control group. The clinic effects of two groups were compared. Before and after the treatment, the levels of PaCO2, PaO2, pH, CRP, ESR and classification of neutrophils were detected in the two groups. The release time of lung shadow, high fever, cough and lung sound in the two groups were observed. The rates of complication and adverse action were observed. Resnlts In the treatment group, the total effective rate was 90.7% , significantly higher than 69.8% in the control group （ P 〈 0.05 ）. The levels of PaO2 and PH were （ 73.64 ±7.74） mm Hg and （ 7.35 ± 0.15 ） in the treat- ment group, significantly higher than that in the control group （ P 〈 0.05 ） , while the level of PaCO2, CRP, ESR and classification of neutrophils were （49.45 ± 6.78） mm Hg, （23.38 ± 3.36） mg/L, （32.87 ± 4.62） mm/h and （43.62 ± 6.72） %, significantly lower than the control group （P 〈 0.05 ）. The release time of symptom were signifi- cantly shorter in the treatment group than which in the control group （ P 〈 0.05 ）. There were no serious complication and adverse actions occurred in the patients. Conclusion The effect of asarone injection combined with bronchoalveolar lay- age for RMPP in children is affirmative and worth to the next research.

关 键 词：细辛脑注射液 支气管肺泡灌洗术 儿童难治性支原体肺炎 

分 类 号：R725.6[医药卫生—儿科] R563.15[医药卫生—临床医学]