不同血液净化方式对终末期肾病炎症因子及相关指标的影响  

Effects of Different Blood Purification Methods on Inflammatory Factors and Related Indicators in Patients with End-stage Renal Disease

作　　者：谭惠丰 曹沛莲 Tan Hui-feng;CAO Pei-lian(Zhangjiagang Hospital of Traditional Chinese Medicine, Medical School of Nanjing University, Jiangsu Zhangjiagang 215600)

机构地区：[1]江苏省张家港市中医医院,江苏张家港215600 [2]江苏省张家港市江苏大学附属澳洋医院,江苏张家港215600

出　　处：《医学临床研究》2018年第5期909-911,共3页Journal of Clinical Research

摘　　要：【目的】探讨不同血液净化方式对终末期肾病（ESRD）患者炎症因子及血尿素氮（BUN）、甲状旁腺激素（PTH）、82微球蛋白（β2-MG）水平的影响。【方法】80例行维持性血透（MHD）患者分为常规血液透析（HD）组（A组）和HD＋血液灌注（HP）组（B组），各40例。治疗6个月后比较两组炎症因子及相关指标变化。计算残余肾功能（RRF），测定BUN、C反应蛋白（CRP）、白介素-6（IL-6）、血浆同型半胱氨酸（Hcy）、PTH、β2-MG水平。【结果】治疗后两组RRF、BUN均下降，但B组RRF、BUN均高于A组，且差异有显著性（P〈0．05）；B组透析后CRP、IL-6、Hcy、PTH、β2-MG均较透析前下降（P〈0．05），A组透析前后比较无明显变化，两组透析后比较差异有显著性（P〈0．05）。【结论】与HD相比，HD＋HP治疗ESRD患者可清除炎性因子及PTH、β2-MG，减轻对RRF的损害。[Objective]To investigate the effects of two different blood purification methods on the levels of inflammatory factors, blood urea nitrogen （BUN）, parathyroid hormone （PTH） and β2-microglobulin （β2-MG） in patients with end-stage renal disease （ESRD）. [Methods]A total of 80 cases of patients undergoing maintenance hemodialysis （MHD） were divided into two groups： group A with routine hemodialysis and group B with routine hemodialysis combined with hemoperfusion （ HP）, with 40 cases in each group. After 6 months of treatment, the residual renal function （RRF） was calculated. The levels of BUN, C reactive protein （CRP）, interleukin-6 （IL-6）, plasma homocysteine （Hcy）, PTH and β2-MG were determined. [Results]After hemodialysis, the value of RRF and BUN decreased in both groups; however, RRF and BUN in group 13 were higher than those in group A （ P 〈0.05）. After hemodialysis, levels of CRP, IL-6, Hcy, PTH and 132-MG in group B were lower than those before hemodial4ysis （ P 〈0.05）, but these indices did not undergo much change after hemodialysis compared to before in group A. So, there were significant differences between the two groups after hemodialysis （ P 〈0.05）. [Conclusion]Compared to routine hemodialysis, hemodialysis combined with hemoperfusion can clear inflammatory factors as well as PTH and β2-MG in patients with ESRD, and reduce the damage to RRF.

关 键 词：肾透析 血液灌注 肾疾病/治疗 C反应蛋白质 甲状旁腺素 Β2微球蛋白 

分 类 号：R692[医药卫生—泌尿科学]