冠心病患者血浆N-末端促生长抑素水平变化及其临床意义  

Level changes and its clinical significance of plasma N-terminal somatostatin in patients with coronary heart disease

作　　者：胡军民 王世俊[2] 黄伟萍[2] 陈捷[2] HU Jun-min;WANG Shi-jun;HUANG Wei-ping;CHEN Jie(Clinical Laboratory, Health Center of Guanhaiwei Town, Cixi, Zhejiang 315314, China)

机构地区：[1]慈溪市观海卫镇卫生院检验科,浙江慈溪315314 [2]余姚市人民医院检验科,浙江余姚315400

出　　处：《中国卫生检验杂志》2018年第10期1235-1237,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨冠心病患者血浆N-末端促生长抑素(NT-pro SST)水平变化及其临床意义。方法收集冠心病患者78例和健康者40例。采用ELISA法测定血浆NT-pro SST水平,比较其在不同分组间的差异。结果观察组血浆NT-pro SST浓度较对照组明显升高,差异有统计学意义(P<0.05)。不同性别间比较,男性观察组血浆NT-pro SST浓度较对照组明显升高;女性观察组血浆NT-pro SST浓度较对照组明显升高,差异均有统计学意义(P<0.05)。冠心病患者(1~30)分组、(31~90)分组及>90分组中血浆NT-pro SST浓度逐渐升高,且各组间差异有统计学意义(P<0.05)。结论血浆NT-pro SST的升高可能与冠心病的发生发展有关,且与冠状动脉病变严重程度呈正相关。Objective To investigate the level changes and its clinical significance of plasma N-terminal somatostatin（ NT-pro SST） in patients with coronary heart disease. Methods 78 cases of coronary heart disease and 40 cases of healthy subjects were enrolled in this study. The levels of plasma NT-pro SST were measured by enzyme-linked immuno sorbent assay（ ELISA）,and their differences among different groups were compared. Results The concentration of plasma NT-pro SST in the observation group was significantly higher than that in the control group,and the difference was statistically significant（ P〈0. 05）. The NT-pro SST concentration in the male observation group was significantly higher than that in the control group. The plasma NT-pro SST concentration in the female observation group was significantly higher than that in the control group,and the differences were statistically significant（ P〈0. 05）. The concentrations of plasma NT-pro SST in patients with CHD（ 1-）,（ 31-90） and 〉90 groups increased gradually,and the differences were statistically significant among the groups（ P〈0. 05）.Conclusion The increase of plasma NT-pro SST may be related to the occurrence and development of coronary heart disease,and is positively correlated with the severity of coronary artery disease.

关 键 词：冠心病 N-末端促生长抑素 GENSINI积分 临床意义 

分 类 号：R541.4[医药卫生—心血管疾病]