本院2013年-2015年乙型肝炎两对半检测结果分析及表面抗原钩状效应的处理  

Analysis of two and a half pairs of hepatitis B in our hospital from 2013 to 2015 and treatment of hook-like effect of surface antigens

作　　者：邓涛 DENG Tao(Lishui District Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu 210000, China)

机构地区：[1]南京市溧水区中医院,江苏南京210000

出　　处：《中国卫生检验杂志》2018年第10期1264-1266,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的对2013年-2015年5 115例就诊者HBV血清标志物(HBs Ag、抗-HBs、HBe Ag、抗-HBe和抗-HBc)结果进行比较分析,为HBV感染者早发现早治疗提供依据。方法采用全自动化学发光分析仪对5 115例标本及其中320例阳性和5例HBs Ag低值而HBe Ag阳性标本进行检测。结果 3年来5 115例就诊者HBs Ag阳性率男性分别为7.12%、6.58%、6.47%,女性分别为5.75%、5.67%、5.59%;HBV感染与年龄有关,男性阳性率从50.27%降至2.70%,女性从51.11%降至0.74%;320例HBV感染者不论男女血清HBs Ag、HBe Ag、抗-HBc水平较正常对照组显著增高,抗-HBs和抗-HBe水平基本正常;1号~5号样倍比稀释后计算结果逐渐增加,呈现钩状效应。结论对患者乙型肝炎病毒检验,不仅能准确判断患者有无HBV感染,还能对乙型肝炎病毒的传染性进行判断,对临床治疗及预防HBV感染带来重要的指导意义。Objective To compare and analyze the results of HBV serological markers（ HBs Ag,anti-HBs,HBe Ag,anti-HBe and anti-HBc） in 5 115 cases of treatments groups from 2013 to 2015,so as to provide basis for early detection and early treatment of HBV infection. Methods 5 115 specimens and 320 positive cases and 5 specimens with low HBs Ag and positive HBe Ag were detected by automatic chemiluminescence analyzer. Results The positive rate of HBs Ag in 5 115 outpatients in three years were 7. 12%,6. 58% and 6. 47% for men,respectively,and 5. 75%,5. 67% and 5. 59% for women,respectively.HBV infection was related to age,and the positive rate of men reduced from 50. 27% to 2. 70%. And that in women decreased from 51. 11% to 0. 74%. The levels of serum HBs Ag,HBe Ag and anti-HBc in 320 cases of HBV infection in both men and women were significantly higher than those in normal control group,and the levels of anti-HBs and anti-HBe were almost normal. The increase in the value of the calculated result after dilution of NO. 1-5 samples presented hook-like effect. Conclusion Hepatitis B virus test in patients can not only accurately determine whether the patients are infected by HBV,but also determine the transmissibility of hepatitis B virus,which has an important guiding significance for the clinical treatment and prevention of HBV infection.

关 键 词：乙型肝炎病毒 乙型肝炎病毒表面抗原 乙型肝炎病毒表面抗体 乙型肝炎病毒E抗原 乙型肝炎病毒e抗体 乙型肝炎病毒核心抗体 钩状效应 

分 类 号：R512.62[医药卫生—内科学]