平阳霉素硬化治疗早期外周动静脉畸形  

Pingyangmycin sclerotherapy for early-stage peripheral arteriovenous malformations

作　　者：吴湘杰[1] 伍霞芳[2] 罗春芬[1] 毛赛克 黎胜苗[1] 於林军[1] Wu Xiangjie;Wu Xiafang;Luo Chunfen;Mao Saike;Li Shengmiao;Yu Linjun(Department of Pediatric Surgery, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Taizhou 317000, China)

机构地区：[1]温州医科大学附属浙江省台州医院小儿外科,317000 [2]温州医科大学附属浙江省台州医院超声科,317000

出　　处：《中华整形外科杂志》2018年第5期343-347,共5页Chinese Journal of Plastic Surgery

摘　　要：目的探讨平阳霉素（博莱霉素A5）硬化治疗早期外周动静脉畸形（arteriovenous malformation，AVM）的安全性及有效性。方法收集2012年1月至2015年5月Schobinger临床分期早期（Ⅰ、Ⅱ期）外周AVM病例13例，其中Ⅰ期11例，Ⅱ期2例，年龄3个月至51岁。在B超或DSA定位下经皮于血管腔及弥散病灶的边缘病灶区域注射平阳霉素硬化剂，所有患者术前、术后均进行了相关辅助检查，分别依据患者临床症状的改善情况和影像学复查病灶的消退情况进行疗效评价。结果所有患者均完成治疗及治疗后随访，随访3-6年。13例患者共注射治疗88次，平均6.7次。疗效评价：7例基本治愈，3例明显改善，2例部分改善，1例无效。其中7例患者术后均有不同程度地肿胀，后自行消退，无严重并发症。结论平阳霉素硬化剂注射治疗早期外周AVM有效、并发症少，可以控制病变进一步发展。Objective To investigate the safety and efficacy of pingyangmycin （bleomycin AS） sclerotherapy for early peripheral arteriovenous malformations （AVM）. Methods Thirteen cases of earlystage [ Schobinger clinical stage （ Ⅰ/Ⅱ ） ] peripheral AVM patients （11 stage Ⅰ and 2 stage Ⅱ patients） aged between 3 months and 51 years were selected between January 2012 and May 2015. Pingyangmycin selerotherapy injections were administered with B-scan ultrasonography or digital subtraction angiography positioning. All patients underwent relevant supplementary examinations before and after the procedure, and clinical evaluation was performed based on the improvement of the clinical symptoms of the patient and re-examination of lesion by imaging. Results A total of 88 injections were administered to the 13 patients with an average of 6.7 injections per patient, 3 - 6 years of follow-up. Based on clinical evaluation, 7 patients were generally cured, 3 patients had significant improvement, 2 patients had partial improvement, and 1 patient had no improvement. Seven patients had different levels of postoperative swelling that resolved on its own. No serious complications occurred. Conclusions Pingyangmycin sclerotherapy for treatment of early peripheral AVM was effective and had few complications. It can control further progression of oathological changes.

关 键 词：平阳霉素 硬化剂注入疗法 动静脉畸形 

分 类 号：R543.6[医药卫生—心血管疾病]