氟哌噻吨美利曲辛对伴焦虑及抑郁突发性聋患者不同阶段的疗效观察  

Efficacy of flupentixol melitracen on curative effect of sudden deafness patients with anxiety and depression in different stages

作　　者：张田 喻国冻 ZHANG Tian;YU Guodong(Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, 550002, Chin)

机构地区：[1]贵州医科大学附属医院耳鼻咽喉头颈外科,贵阳550002

出　　处：《临床耳鼻咽喉头颈外科杂志》2018年第9期643-646,652,共5页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：贵阳市科技计划项目[No:筑科合同(2012103)29号]

摘　　要：目的:探讨氟哌噻吨美利曲辛对伴焦虑及抑郁的突发性聋患者不同阶段的疗效。方法:选取163例伴焦虑及抑郁的突发性聋患者,随机分成2个组:实验组(81例)和对照组(82例)。所有患者给予常规治疗,疗程2周,实验组在该基础上再予氟哌噻吨美利曲辛口服(1片/d),疗程3个月。观察比较实验组和对照组治疗后听力、耳鸣疗效和眩晕疗程,治疗后2周、3个月和6个月的耳鸣治愈率,焦虑状态量表(SAS)、抑郁状态量表(SDS)评分。结果:实验组听力总有效率、耳鸣总有效率为86.42%和84.21%,均高于对照组(67.07%、61.29%);实验组患者眩晕痊愈治疗时间为(5.79±2.22)d,小于对照组[(10.21±3.42)d],差异有统计学意义(P<0.05)。治疗后2组患者的平均听阈值均较治疗前下降,且实验组低频下降型、高频下降型、平坦下降型及全聋型的听阈值均低于对照组(均P<0.05)。治疗后3个月及6个月,实验组耳鸣治愈率高于对照组(P<0.05)。2组治疗后2周、3个月及个6个月SAS、SDS评分均较治疗前下降;实验组治疗后2周、3个月及6个月SAS、SDS评分下降,两两比较显示实验组不同时间点均差异有统计学意义(P<0.05);治疗后同时间点实验组SAS、SDS评分均低于对照组(P<0.05)。结论:对于伴焦虑和抑郁的SD患者,在常规治疗基础上,联合应用氟哌噻吨美利曲辛能够进一步提高临床疗效、患者的精神状态和耳鸣远期治疗疗效。Objective：To investigate the efficacy of flupentixol melitracen on different stages of sudden deafness patients with anxiety and depression.Method：Totally one hundred and sixty-three sudden deafness patients with anxiety and depression were randomly divided into two groups：experimental group（81 cases）and control group（82 cases）.All patients were given routine treatment for 2 weeks.The experimental group was given oral flupentixol melitracen（1 tablet/day）for a period of 3 months.The hearing,tinnitus effect and vertigo treatment course were observed and compared.Curing rate of tinnitus at 2 weeks,3 months and 6 months after treatment,self-rating anxiety scale（SAS）and depressive state scale（self-rating depression scale,SDS）score were collected and compared.Result：Total efficiency of hearing and tinnitus of experimental group（86.42%,84.21%）were higher than those of the control group（67.07%,61.29%）;the vertigo cured the average treatment time of experimental group（5.79±2.22）days was less than that of the control group（10.21±3.42）days,all the differences were statistically significant（P〈0.05）.After the treatment,the average hearing thresholds of the two groups were lower than those before the treatment,and the hearing thresholds of the low frequency descent type,highfrequency descent type,flat down type and total deafness type in the experimental group were lower than those in the control group,all the differences were statistically significant（P〈0.05）.The tinnitus cure rate of the experiment group were higher than that of the control group at 3 months and 6 months after treatment,the differences were statistically significant（P〈0.05）;and after 3 months and 6 months treatment tinnitus cure rate of the experimental group was higher than that of after 2 weeks the treatment,the difference was statistically significant（P〈0.05）.The SAS and SDS scores of the two groups at 2 weeks,3 months and 6 months were lower than those before treatment.The SAS and SDS

关 键 词：突发性聋 氟哌噻吨美利曲辛 耳鸣 焦虑 抑郁 

分 类 号：R764.43[医药卫生—耳鼻咽喉科]