氟比洛芬酯对老年宫颈癌患者术后镇痛及认知功能的影响  

Effects of Flurbiprofen Axetil on Postoperative Analgesia and Cognitive Function in Elderly Patients with Cervical Cancer

作　　者：董天鑫[1] 赵磊[2] 李艳[1] 王文东 曹雪峰[1] 刘玉伶[1] 段凤梅[1] 连相尧[3] DONG Tianxin1, ZHAO Lei2, LI Yan1, WANG Wendong1, CAO Xuefeng1, LIU Yuling1 , DUAN Fengmei1, LIAN Xiangyao3(1. Dept. of Anesthesiology, Affiliated Hospital of Chengde Medical College, Hebei Chengde 067000, China; 2. Dept. of Cancer Center, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, China; 3. Dept. of Oncology, Affiliated Hospital of Chengde Medical College, Hebei Chengde 067000, Chin)

机构地区：[1]承德医学院附属医院麻醉科,河北承德067000 [2]首都医科大学附属友谊医院肿瘤中心,北京100050 [3]承德医学院附属医院肿瘤科,河北承德067000

出　　处：《中国医院用药评价与分析》2018年第5期583-585,共3页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：北京市自然科学基金青年项目(No.7184200)

摘　　要：目的:探讨氟比洛芬酯对老年宫颈癌患者术后镇痛及认知功能的影响。方法:将宫颈癌根治术实施全身麻醉且术后接自控镇痛泵镇痛的患者60例以随机数字表法分为氟比洛芬酯联合舒芬太尼组(FA组)和舒芬太尼组(F组),每组30例。FA组患者给予氟比洛芬酯2.5 mg/kg+舒芬太尼1μg/kg+0.9%氯化钠注射液200 ml,F组患者给予舒芬太尼2.5μg/kg+0.9%氯化钠注射液200 ml。于术前24 h和术后12、24及48 h,评定两组患者的视觉模拟评分(visual analog score,VAS);于术前1 d和术后3、5及7 d,评定两组患者的简易智力状态检查量表(mini-mental state examination,MMSE)评分;于术后3、5及7 d,观察两组患者术后认知功能障碍发生情况。结果:FA组患者术后各时点的VAS评分均明显低于F组,差异均有统计学意义(P<0.05);术后3 d,FA组患者的MMSE评分明显高于F组,术后认知功能障碍发生率明显低于F组,差异均有统计学意义(P<0.05)。结论:氟比洛芬酯联合舒芬太尼用于老年宫颈癌患者术后镇痛效果满意,在一定程度上降低了术后认知功能障碍的发生率。OBJECTIVE： To probe into the effects of flurbiprofen axetil on postoperative analgesia and cognitive function in elderly patients with cervical cancer. METHODS： 60 patients undergoing radical hysterectomy with general anesthesia and postoperative patient-controlled analgesia were divided into FA group（ flurbiprofen axetil combined with sufentanil） and F group（ sufentanil） via random number table,with 30 cases in each. FA group was given 2. 5 mg/kg of flurbiprofen axetil combined with 1 μg/kg of sufentanil and 200 ml 0. 9% of sodium chloride injection,while F group was given 2. 5 μg/kg of sufentanil and 200 ml 0. 9% of sodium chloride injection. Visual analog score（ VAS） of two groups were evaluated at 24 h before operation and 12 h,24 h,48 h after operation; scores of mini-mental state examination（ MMSE） of two groups were evaluated at 1 d before operation and 3 d,5 d,7 d after operation; incidences of cognitive disorder of two groups were observed at 3 d,5 d and 7 d after operation. RESULTS： VAS of FA group at every time-point were significantly lower than those of F group,with statistically significant difference（ P〈0. 05）; at 3 d after operation,the MMSE score of FA group was significantly higher than that of F group,the incidence of cognitive disorder was significantly lower than that of F group,with statistically significant differences（ P〈0. 05）. CONCLUSIONS： The effect of flurbiprofen axetil combined with sufentanil on postoperative analgesia and cognitive function in elderly patients with cervical cancer is remarkable,which can reduce the incidence of postoperative cognitive disorder at a certain degree.

关 键 词：氟比洛芬酯 术后认知功能障碍 宫颈癌 

分 类 号：R971[医药卫生—药品]