益气养阴活血方治疗肺纤维化患者疗效及对患者炎性因子和肺功能的影响  

Efficacy of Yiqi Yangyin Huoxue Fang on Patients with Pulmonary Fibrosis and Effects on Inflammatory Factors and Pulmonary Function

作　　者：于国强[1] 庞立健[2] 付东升[1] 石绍顺[1] 李明飞[1] 李丁蕾[1] Yu Guoqiang;Pang Lijian;Fu Dongsheng;Shi Shaoshun;Li Mingfei;Li Dinglei(Department of Respiratory Medicine, Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110034, China;Department of Respiratory Medicine, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China)

机构地区：[1]辽宁中医药大学附属第二医院呼吸内科,沈阳110034 [2]辽宁中医药大学附属医院呼吸内科,沈阳110032

出　　处：《世界中医药》2018年第3期651-654,共4页World Chinese Medicine

基　　金：2014年辽宁省高等学校科学研究一般项目(L2104369)

摘　　要：目的:探讨益气养阴活血方治疗肺纤维化患者的疗效及对患者炎性因子和肺功能影响。方法:选取2014年12月至2016年12月辽宁中医药大学附属第二医院收治的肺纤维化患者94例,按照随机表法分为观察组与对照组,各47例。对照组采用西医治疗,观察组在对照组基础上联合益气养阴活血方治疗。2组疗程均为3个月。结果:观察组总有效率(89.36%)高于对照组(70.21%)(P<0.05);2组治疗后呼吸困难、咳嗽、啰音评分降低(P<0.05);观察组治疗后呼吸困难、咳嗽、啰音评分低于对照组(P<0.05);2组治疗后白介素-6(IL-6)、转化生长因子-β1(TGF-β1)和肿瘤坏死因子-α(TNF-α)降低(P<0.05);观察组治疗后IL-6、TGF-β1和TNF-α低于对照组(P<0.05);2组治疗后FVC、FEV1和DLco增加(P<0.05);观察组治疗后用力肺活量(FVC)、一秒用力呼气容积(FEV1)和单次呼吸法一氧化碳弥散(Dlco)高于对照组(P<0.05);2组均未出现明显不良反应。结论:益气养阴活血方治疗肺纤维化患者疗效显著,可降低炎性因子IL-6、TGF-β1和TNF-α水平,及改善患者肺功能。Objective： To study the curative effect of Yiqi Yangyin Huoxue Fang on pulmonary fibrosis and its influence on inflammatory factors and pulmonary function. Methods： A total of 94 patients with pulmonary fibrosis treated in our hospital from December 2014 to December 2016 were randomly divided into the observation group（ 47 cases） and the control group（ 47 cases）. The control group was treated with western medicine,and the observation group was treated with Yiqi Yangyin Huoxue Fang on the basis of the control group. The two groups were treated for 3 months. Results： The total effective rate of the observation group（ 89. 36%） was higher than that of the control group（ 70. 21%）（ P 〈0. 05）; Cough,breathing difficulties and the two groups after treatment were lower rales（ observation group： t = 22. 5430,24. 0091,21. 9675,the control group： t = 14. 0037,14. 9906,15. 1712,P 〈0. 05）; respiratory difficulties,cough,rales in the observation group after treatment were lower than control group（ t = 20. 2334,10. 8108,12. 9694,P〈 0. 05）; IL-6,TGF-β1 and TNF-α decreased in two groups after treatment（ observation group： t = 25. 4017,16. 6851,24. 3335,the control group： t = 10. 7510,9. 7017,12. 1940,P 〈0. 05）; the observation group after treatment IL-6,TGF-β1 and TNF-α lower than that of the control group（ t = 14. 8318,13. 2045,13. 2847,P 〈0. 05）. The two groups after treatment FVC,FEV1 and DLco increased（ observation group： t = 12. 4157,14. 2608,11. 5487,the control group： t = 7. 5293,8. 5027,5. 9400,P 〈0. 05） and the observation group after treatment FVC,FEV1 and DLco was higher than the control group（ t = 6. 1000,5. 9271,5. 2539,P〈 0. 05）. There were no obvious adverse reactions in the two groups. Conclusion： Yiqi Yangyin Huoxue Fang has significant curative effect on pulmonary fibrosis,can reduce the levels of inflammatory factors IL-6,TGF-β1 and TNF-α,and improve the lung function of patients,which has important research significance.

关 键 词：益气养阴活血方 肺纤维化 疗效 白介素-6 转化生长因子-β1 肿瘤坏死因子-α 用力肺活量 一秒用力呼气容积 单次呼吸法一氧化碳弥散 

分 类 号：R289.5[医药卫生—方剂学] R563[医药卫生—中药学]