围绝经及激素替代治疗对免疫功能影响的研究进展  

Research progress of impact of menopause and menopausal hormone therapy on immunity

作　　者：周杨[1] 陶敏芳[1] ZHOU Yang;TAO Min-fang(Department of Gynecology and Obstetrics, the Sixth People＇s Hospital, Shanghai Jiao Tong University, Shanghai 200233, Chin)

机构地区：[1]上海交通大学附属第六人民医院妇产科,上海200233

出　　处：《中国妇幼健康研究》2018年第5期561-565,共5页Chinese Journal of Woman and Child Health Research

基　　金：上海市第六人民医院预研基金资助项目(LYZY-0130);上海市科委基金资助项目(15411950202)

摘　　要：(围)绝经期妇女由于性激素降低,导致神经-内分泌-免疫网络紊乱,影响机体免疫功能。目前激素替代疗法(MHT)对于改善妇女更年期症状、预防心血管、骨质疏松等疾病的疗效已受到肯定,但对免疫系统的作用,能否阻止免疫衰老还缺乏统一认识。该文综述近年来国内外文献,就(围)绝经期及激素替代治疗后T细胞免疫网络及免疫炎症指标的变化进行总结分析。It＇s known that the loss of ovarian steroids in （peri-） postmenopausal women leads to the deregulation of neuro- endocrine-immune, resulting in general decline in immune function. Nowadays menopausal hormone therapy （MHT） has been spoken highly of its effect in relieving climacteric syndrome, preventing cardiovascular diseases, osteoporosis, etc, but the role of MHT in preventing immunosenescence is not yet fully understood. This review covered literatures both home and abroad in recent years, summarized and analyzed the impact of the menopause and MHT on T lymphocyte immune network and inflammatoryimmune biomarkers.

关 键 词：绝经 激素替代治疗 T淋巴细胞免疫网络 急性期反应蛋白 

分 类 号：R711.75[医药卫生—妇产科学]