2008～2016年江西省重症手足口病流行病学及病原学特征分析  

Analysis of the Epidemiological and Etiological Characteristics of Severe Hand,Foot and Mouth Disease in Jiangxi Province,China,2008～2016

作　　者：郭悦 熊英[2] 王英[1] 冀天娇[1] 龚甜[2] 李健雄[2] 杨倩[1] 张艳妮[2] 周珺[2] 徐刚[2] 施勇[2] 许文波[1] GUO Yue;XIONG Ying;WANG Ying;JI Tianjiao;GONG Tian;LI Jianxiong;YANG Qian;ZHANG Yanni;ZHOU Jun;XU Gang;SHI Yong;XU Wenbo(Key Laboratory of Medical Virology Ministry of Health, National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention, Beijing 100206, China;Jiangxi Center for Disease Control and Prevention, Nanchang 330029,China)

机构地区：[1]中国疾病预防控制中心病毒病预防控制所卫生部医学病毒病重点实验室,北京102206 [2]江西省疾病预防控制中心,南昌330029

出　　处：《病毒学报》2018年第3期334-341,共8页Chinese Journal of Virology

基　　金：国家科技重大专项(项目号:2012ZX10004-201),题目:自然疫源性传染病病原谱流行规律及变异研究~~

摘　　要：为阐明江西省重症手足口病（Hand,foot and mouth disease,HFMD）的流行病学和病原学特征,本研究利用2008-2016年江西省重症HFMD的监测数据,采用描述性流行病学方法对重症病例三间分布和病原构成进行系统分析,并对本省引起重症HFMD的肠道病毒71型（Enterovirus A71,EV-A71）进行基因特征分析。2008-2016年全省报告重症病例2 255例,在全国排名第15位,重症死亡病例120例;重症病例数至2011年达到高峰,此后整体呈下降趋势;各个地市均有上报,尤以宜春市、南昌市和上饶市重症数较多;除2008年外,各年重症病例数呈双峰分布,大多数年份夏季为主高峰,秋冬季为次高峰;5岁以下散居儿童为最主要发病人群,男性多于女性。EVA71是重症HFMD绝对优势病原体,占重症确诊病例的81.89%。对引起重症HFMD的72株江西省EV-A71分离株VP1编码区进行基因测定和分析,显示均属于C4基因亚型的C4a进化分支。本研究提示5岁以下散居儿童应为重症HFMD重点防护人群,江西省引起重症的C4a进化分支属于我国EV-A71最常见的基因型别。We wished to clarify the epidemiological and etiological characteristics of severe hand,foot and mouth disease（HFMD）in Jiangxi Province,China,based on the surveillance data of severe HFMD in Jiangxi Province from 2008 to 2016,this study systematically analyzed the spatial and temporal characteristics and pathogenic form of severe HFMD,as well as the gene characteristics of enterovirus A71（EVA71）which caused severe HFMD in Jiangxi Province of China,using a descriptive epidemiological method.During 2008 to 2016,2,255 cases of severe HFMD and 120 fatalities among severe HFMD cases were reported in the entire Province,reached a peak in 2011,and then the overall trend was declining.All cities within Jiangxi Province reported severe cases,especially Yichun,Nanchang and Shangrao.In addition to2008,there were two peaks in the number of severe cases each year,with the main peak occurring in the summer and smaller peaks in the autumn and winter.Morbidity was greatest in children under 5 years old of age.The number of severe cases among men was higher than that in women.EV-A71 was the dominant pathogen of severe HFMD,accounting for 81.89% of confirmed severe cases.Gene detection and analyses of 72 VP1 coding regions of EV-A71 isolates from cases of severe HFMD in Jiangxi Province showed that these EV-A71 isolates belonged to the C4 aevolution branch of the C4 sub-genotype.Our study suggests that children under 5 years of age are the target population,and should be protected.The C4 aevolutionary branch found in severe cases of HFMD in Jiangxi Province belonged to the most common genotype of EVA71 in China.

关 键 词：重症手足口病 肠道病毒71型 流行病学 病原学 江西省 

分 类 号：R373.2[医药卫生—病原生物学]