评价血液灌流法在急性重症安眠药中毒急诊治疗中的效果  

Evaluation of the effect of hemoperfusion in emergency treatment of acute severe hypnotic poisoning

作　　者：刘传令 LIU Chuan-ling.(Department of Emergency, Shandong Shanxian County Haijiya Hospital, Heze 274300, Chin)

机构地区：[1]山东省单县海吉亚医院急诊科,274300

出　　处：《中国实用医药》2018年第15期32-34,共3页China Practical Medicine

摘　　要：目的评价血液流灌法在急性重症安眠药中毒急诊治疗中的效果。方法 64例急性重症安眠药中毒患者,随机分成观察组和对照组,各32例。对照组予以基础治疗,观察组在对照组基础上予以血液灌流法治疗。对比两组平均苏醒时间及住院时间、生理指标[收缩压(SBP)、舒张压(DBP)、心率(HR)、动脉血氧分压(PaO_2)、血二氧化碳分压(PaCO_2)]并发症发生情况。结果观察组平均苏醒时间(8.6±2.1)h及平均住院时间(5.4±2.6)d均短于对照组的(15.3±4.2)h、(10.5±3.5)d,差异有统计学意义(P<0.05);观察组的生理指标DBP(121.3±22.1)mm Hg(1 mm Hg=0.133 kPa)高于对照组的(110.2±19.2)mm Hg,BCP(82.4±10.6)mm Hg、PaO_2(10.2±0.5)kPa、PaCO_2(5.0±0.2)kPa、HR(65.1±5.3)次/min均低于对照组的(89.7±16.8)mm Hg、(10.9±1.6)kPa、(5.4±0.8)kPa、(69.8±7.6)次/min,差异有统计学意义(P<0.05);观察组的并发症发生率12.50%低于对照组的43.75%,差异有统计学意义(P<0.05)。结论血流灌流法联合基础治疗在急性重症安眠药中毒急诊治疗中效果确切,不仅可以帮助患者快速恢复,缩短住院时间,还能让患者各项生理指标迅速恢复正常,减少并发症情况,值得推广。Objective To evaluate the effect of hemoperfusion in emergency treatment of acute severe hypnotic poisoning. Methods A total of 64 patients with acute severe hypnotic poisoning were randomly divided into observation group and control group, with 32 cases in each group. The control group received basic treatment, and the observation group received hemoperfusion on the basis of Control group. Comparison were made on wake-up time, hospitalization time, physiological indexes[including systolic blood pressure（SBP）, diastolic blood pressure（DBP）, heart rate（HR）, arterial oxygen partial pressure（PaO2）, blood pressure of carbon dioxide（PaCO2）], and the occurrence of complications between the two groups. Results The observation group had shorter mean wake-up time as（8.6±2.1） h and mean hospitalization time as（5.4±2.6） d than（15.3±4.2） h and（10.5±3.5） d in the control group, and their difference was statistically significant（P〈0.05）. The observation group had higher physiological index SBP as（121.3±22.1） mm Hg（1 mm Hg=0.133 kPa） than（110.2± 19.2） mm Hg in the control group, and lower DBP as（82.4±10.6） mm Hg, PaO2 as（10.2±0.5）kPa, PaCO2 as（5.0±0.2） kPa and HR as（65.1±5.3） times/min than（89.7±16.8） mm Hg,（10.9±1.6） kPa,（5.4±0.8） kPa and（69.8±7.6） times/min in the control group. Their difference was statistically significant（P〈0.05）. The observation group had lower incidence of complications as 12.50% than 43.75% in the control group, and the difference was statistically significant（P〈0.05）. Conclusion Combination of hemoperfusion and basic treatment shows affirmative effect in emergency treatment of acute severe hypnotic poisoning, it can not only help patients recover quickly, shorten hospitalization time, but also help recover their physiological indexes quickly and reduce the complications. It is worth popularizing.

关 键 词：血液流灌法 急性重症安眠药中毒 急诊 

分 类 号：R595.4[医药卫生—内科学]