高压氧对稳定期慢性阻塞性肺疾病患者细胞免疫功能的影响  

Effects of hyperbaric oxygen on cellular immune function in the patients with stable chronic obstructive pulmonary disease

作　　者：马永信[1] 刘召粉[1] 于砚丽[1] 张振英[1] 刘晓霞 Ma Yongxin;Liu Zhaofen;Yu Yanli;Zhang Zhenying;Liu Xiaoxia(Department of Hyperbaric Oxygen, Weifang People＇s Hospital, Weifang 261041, China)

机构地区：[1]潍坊市人民医院康复医学科高压氧治疗中心,山东省潍坊261041 [2]山东潍坊滨海经济开发区人民医院高压氧治疗室

出　　处：《中华航海医学与高气压医学杂志》2018年第2期99-102,共4页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的观察稳定期慢性阻塞性肺疾病（chronic obstructive pulmonary diseases, COPD）患者的细胞免疫水平，探讨高压氧（hyperbaric oxygen, HBO）治疗对稳定期COPD患者细胞免疫功能的影响。方法选择2012年1月至2015年2月在潍坊市人民医院呼吸内科住院的稳定期COPD患者167例为研究对象，按治疗方法分为2组，其中药物吸入组81例，吸入噻托溴胺雾化溶液；HBO组86例，在吸入噻托溴胺雾化溶液的基础上进行HBO治疗；另选33例正常健康人群为正常对照组。检测分析治疗前后各组细胞免疫功能指标。结果HBO组和药物吸入组患者白细胞介素-2受体（IL-2R）[（218.95±106.60） μg/ml、（235.60±67.85）μg/ml]、淋转率[（42.15±5.75）%、（42.52±5.75）%]、CD3[（47.05±7.76）%、（47.20±7.63）%]、CD4[（36.20±6.05）%、（34.67±4.51）%]与正常对照组[（389.13±191.42）μg/ml、（77.60±5.29）%、（65.70±6.30）%、（44.50±4.70）%]比较差异有统计学意义（P〈0.01）。HBO组患者治疗后细胞免疫指标显著改善、肺通气功能明显提高、低氧血症明显改善，与治疗前比较差异均有统计学意义（P〈0.05）；HBO组患者治疗后细胞免疫指标与药物吸入组比较明显改善，差异均有统计学意义（P〈0.01）。结论稳定期COPD患者的细胞免疫水平均有不同程度的降低，HBO治疗能明显改善稳定期COPD患者的细胞免疫功能，纠正患者的缺氧和CO2潴留，提高患者的肺通气功能。ObjectiveTo observe the level of cellular immune function in the patients with stable chronic obstructive pulmonary disease（COPD）, and also to investigate the effects of hyperbaric oxygen （HBO） on the cellular immune function in the patients with stable COPD. MethodsOne hundred and sixty-seven cases of stable COPD were divided into 2 groups, the drug inhalation group （n=81）, which inhaled tiotropium bromide and the HBO group （n=86）, which received HBO therapy in addition to drug inhalation. Another 33 normal health subjects were recruited as the normal control group. Immune function indexes of the 3 groups were detected and analyzed before and after therapy.ResultsThe IL-2R level and lymphatic metastasis rate of the HBO group and the drug inhalation group were respectively [（218.95±106.60） μg/ml, （235.60±67.85）μg/ml] and [（42.15±5.75）%, （42.52±5.75）%], CD3 and CD4 levels were respectively [（47.05±7.76）%, （47.20±7.63）%] and [（36.20±6.05）%, （34.67±4.51）%]. Statistical significance could be found when they were compared with those of the normal control group [（389.13±191.42）μg/ml, （77.60±5.29）%, （65.70±6.30）%, （44.50±4.70）%]（P〈0.01）. For the HBO group, significant improvement could be seen in cellular immune indexes, pulmonary ventilation function and hypoxemia after therapy, and there was statistical significance when compared with those data before therapy（P〈0.05）. There was also significant improvement in cellular immune indexes for the patients of the HBO group, as compared with those of the drug therapy group, and statistical significance could be noted when comparisons were made between the 2 groups（P〈0.01）.ConclusionsThe cellular immune levels of the patients with stable COPD were decreased to various degrees. HBO therapy could significantly improve thecellular immune function of the patients with stable COPD, rectify hypoxia and carbon dioxide retention and improve pulmonary function.

关 键 词：高压氧 慢性阻塞性肺疾病 细胞免疫功能 

分 类 号：R563.9[医药卫生—呼吸系统]