线粒体相关内质网膜(MAM)钙转运及调节蛋白介导线粒体钙稳态  

The Role of Mitochondria-Associated Endoplasmic Reticulum Membranes(MAM) Calcium-Related Proteins in Maintaining Mitochondria Calcium Homeostasis

作　　者：高鹏 杨明[1] 孙林[1] Gao Peng;Yang Ming;Sun Lin(Department of Nephrology, Second Xiangya Hospital, Institute of Nephrology, Central South University, Changsha 410011, China)

机构地区：[1]中南大学湘雅二医院肾内科中南大学肾脏病研究所,长沙410011

出　　处：《中国细胞生物学学报》2018年第4期585-593,共9页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81730018;81470960)资助的课题~~

摘　　要：内质网和线粒体作为细胞内重要的钙池,维持细胞内钙离子稳态。近年来发现,线粒体与内质网之间存在物理偶联,称为线粒体相关内质网膜(mitchondria associated endoplasmic reticulum membrane,MAM)。最近发现,MAM中存在许多钙转运与调节蛋白,它们对内质网与线粒体之间的钙离子交流进行精密调节,维持细胞功能与生存。该文综述了国内外近年来MAM介导的钙离子信号转导的研究进展,重点阐述MAM中钙离子相关蛋白质在维持线粒体钙稳态中的作用与机制。The endoplasmic reticulum（ER） and mitochondria are the main storage compartment for cell calcium, which play an important role in calcium homeostasis. The specific sites of physical association between ER and mitochondria are known as mitochondria-associated endoplasmic reticulum membranes（MAM）. It has recently become clear that MAMs are crucial for highly efficient transmission of Ca^2＋ from the ER to mitochondria, thus controlling fundamental processes involved in energy production, determining cell fate and also mitochondria calcium homeostasis. In this review, we summarize the recent progress of the calcium signaling around MAM, emphasizing the mechanism and functions of Ca^2＋ related proteins of MAM in maintaining mitochondria calcium homeostasis.

关 键 词：线粒体相关内质网膜 Ca^2+转运调节蛋白 线粒体钙稳态 功能 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]