2型糖尿病患者合并动脉粥样硬化危险因素分析  

Risk factors of atherosclerosis in patients with type 2 diabetes

作　　者：石维[1] 陈雷[2] 卜瑞芳[1] Shi Wei;Chert Lei;Bu Ruifang(Department of Endocrinology, Wuxi People＇s Hospital Affiliated to Nanjing Medical University, Jiangsu Province, Wuxi 214000, China;Department of Ultrasonography, Wuxi People＇s Hospital Affiliated to Nanjing Medical University, Jiangsu Province, Wuxi 214000, China)

机构地区：[1]南京医科大学附属无锡市人民医院内分泌科,214000 [2]南京医科大学附属无锡市人民医院超声科,214000

出　　处：《中国医药》2018年第6期879-881,共3页China Medicine

摘　　要：目的探讨2型糖尿病患者合并动脉粥样硬化的危险因素。方法收集2014年8月至2015年8月南京医科大学附属无锡市人民医院收治的2型糖尿病患者200例的病历资料,按照是否合并动脉粥样硬化分为动脉粥样硬化组(126例)和非动脉粥样硬化组(74例),比较2组基本资料与生化指标,分析2型糖尿病患者合并动脉粥样硬化的危险因素。结果动脉粥样硬化组年龄、病程、三酰甘油、低密度脂蛋白胆固醇(LDL-C)水平均明显高于非动脉粥样硬化组[(56±9)岁比(53±8)岁、(6±5)年比(5±4)年、(3.1 1±1.1)mmol/L比(2.7±0.8)mmol/L、(2.7±0.8)mmol/L比(2.2±0.7)mmol/L],而高密度脂蛋白胆固醇(HDL-C)水平明显低于非动脉粥样硬化组[(0.94±0.19)mmol/L比(1.01±0.30)mmol/L],差异均有统计学意义(均P<0.05)。Logistic回归分析结果显示,高龄、长病程、高三酰甘油以及LDL-C水平是2型糖尿病患者合并动脉粥样硬化的独立危险因素,而高HDL-C水平是其保护因素(均P<0.05)。结论高龄、长病程、高三酰甘油和LDL-C、低HDL-C均会促进2型糖尿病患者动脉粥样硬化的发生。Objective To analyze the risk factors of atherosclerosis in patients with type 2 diabetes. Methods Clinical data of 200 patients with type 2 diabetes in Wuxi People′s Hospital Affiliated to Nanjing Medical University from August 2014 to August 2015 were reviewed; the patients were divided into arteriosclerosis group（n＝126） and non-arteriosclerosis group（n＝74）. General information and biochemical indexes were analyzed. Results Age, course of diabetes, levels of triacylglycerol（TG） and low-density lipoprotein cholesterol（LDL-C） in atherosclerosis group were significantly higher than those in non-arteriosclerosis group［（56±9）years vs （53±8）years, （6±5）years vs （5±4）years, （3.1±1.1）mmol/L vs （2.7±0.8）mmol/L, （2.7±0.8）mmol/L vs （2.2±0.7）mmol/L］; high-density lipoprotein cholesterol （HDL-C） level in atherosclerosis group was significantly lower than that in non-arteriosclerosis group［（0.94±0.19）mmol/L vs （1.01±0.30）mmol/L］（all P＜0.05）. Logistic regression analysis showed that advanced age, long course of diabetes, high levels of TG and LDL-C were independent risk factors of arteriosclerosis; high level of HDL-C was a protective factor of arteriosclerosis（P＜0.05）. Conclusion Age, course of disease, levels of TG, HDL-C and LDL-C are closely related to the occurrence of arteriosclerosis in patients with type 2 diabetes.

关 键 词：2型糖尿病 动脉粥样硬化 危险因素 

分 类 号：R587.1[医药卫生—内分泌]