丙种球蛋白联合神经节苷脂治疗小儿病毒性脑炎效果评价  

Evaluation of the effect of c-globulin in the treatment of pediatric viral encephalitis

作　　者：白红丽 马志强[2] BAI Hongli;MA Zhiqiang(） Department of Paediatrics , the Second Affiliated Hospital of Luohe Medical College, Luohe 462000, China;）The First Af filiated Hospital of Henan University ,Kai feng 475001 ,China)

机构地区：[1]漯河医学高等专科学校第二附属医院儿科,河南漯河462000 [2]河南大学第一附属医院,河南开封475001

出　　处：《中国实用神经疾病杂志》2018年第9期979-983,共5页Chinese Journal of Practical Nervous Diseases

基　　金：开封市科技发展计划项目;编号:1703010

摘　　要：目的探讨丙种球蛋白联合神经节苷脂治疗小儿病毒性脑炎的临床效果。方法将漯河医学高等专科学校第一附属医院2014-10—2016-10收治的64例病毒性脑炎患儿随机分为观察组与对照组,每组32例,对照组给予常规治疗,观察组在对照组基础上给予丙种球蛋白加神经节苷脂静滴。结果观察组治疗有效率(93.75%)远高于对照组(75.00%),差异具有统计学意义(P<0.05);观察组退热、精神意识改善、抽搐停止、脑膜刺激征消失以及脑脊液恢复正常时间、住院时间均短于对照组,差异有统计学意义(P<0.05);观察组CGRP表达水平高于对照组,TNF-α、S100B、MBP、NGF各指标表达水平低于对照组,差异均有统计学意义(P<0.05)。结论丙种球蛋白联合神经节苷脂治疗病毒性脑炎效果显著,值得临床推广应用。ObjectiveTo explore the clinical effect of the combination of gamma globulin and ganglioside in the treatment of children with viral encephalitis.Methods From October 2014 to October 2016,64 cases of children with viral encephalitis were randomly divided into observation group and control group,32 cases in each group.Control group were given conventional treatment,observation group was received gamma globulin and ganglioside treatment via intravenous drip.Results The effective rate（93.75%）was significantly higher in the observation group（93.75%）than in the control group（75%）（P〈0.05）.The expression level of CGRP in the observation group was higher than that in the control group.The expression levels of TNF-alpha,S100 B,MBP and NGF were lower than those in the control group,and the differences were statistically significant（P〈0.05）.Conclusion The treatment of viral encephalitis is remarkable and worthy of clinical application.

关 键 词：病毒性脑炎 丙种球蛋白 神经节苷脂 脑膜刺激征 效果评价 

分 类 号：R512.3[医药卫生—内科学]