疱疹病毒隐性感染的机制及意义  

Mechanism of herpes virus latent infection and its significance

作　　者：吴克复 马小彤 郑国光 宋玉华 Wu Kefu;Ma Xiaotong;Zheng Guoguang;Song Yuhua(State Key Laboratory of Experimental Hematology, Institute of Hematology ＆ Blood Diseases Hospital, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Tianfin 300020, Chin)

机构地区：[1]中国医学科学院北京协和医学院血液病医院血液学研究所实验血液学国家重点实验室,天津300020

出　　处：《白血病．淋巴瘤》2018年第5期257-262,共6页Journal of Leukemia & Lymphoma

基　　金：国家自然科学基金（81670158、81470278、81370634、81570153）;天津市自然科学基金重点项目（17JCZDJC35100、17JCZDJC35000）;中国医学科学院课题（2017NL31003）

摘　　要：人类疱疹病毒在人群中以隐性感染方式广为传播，可分为3大类8种类型，引起单纯疱疹的1型、2型，引起水痘和带状疱疹的3型，以及作为首个被确认为人类肿瘤病毒的EB病毒（4型）已广为人知。随着移植治疗开展而受到重视的巨细胞病毒（5型）和6型也日益受到关注。人类疱疹病毒的生物学特性是长期隐性感染，在免疫功能下降时激活致病，阐明其隐性感染机制可以寻找防治靶点，是临床防治的基础。文章概述人类疱疹病毒感染的临床意义，以EB病毒隐性感染的机制研究为例，探讨机体与病毒共进化博弈的途径和意义，探索对策，为防治提供线索。Human herpes virus （HHV） spreads widely in a latent-infected way. HHV is divided into 3 kinds and 8 types. Herpes simplex caused by HHV-1 and HHV-2, varicella-zoster caused by HHV-3 and Epstein-Barr virus （EBV） known as HHV-4 and recognized firstly as human tumor virus, are well known in the field of virology. With the application of hematopoietic stem cell transplantation , cytomegalovirus （HHV-5） and HHV-6 have gained an increasing attention. The biological characteristic of HHV is latent infection in a long time and HHV can be reactivated in some immunocompromised individuals. Clarification of latent infection mechanism will help provide targets for therapy and lay a foundation for clinical treatment. This paper summarizes the clinical significance of HHV infection. Taking the mechanism of EBV latent infection as an example, the pathway and significance as well as strategy of co-evolution of organism and virus will be discussed in order to provide clues for prevention and therapy.

关 键 词：单纯疱疹病毒属 隐性感染 疱疹病毒4型 人 

分 类 号：R511[医药卫生—内科学]