基于数据挖掘和整合药理学的人参用药规律分析及治疗冠心病的分子机制探讨  

Ginseng prescription rules and molecular mechanism in treating coronary heart disease based on data mining and integrative pharmacology

作　　者：李森[1] 唐仕欢[2] 刘金玲[1] 苏瑾 贺福元[1,3,4,5] LI Sen;TANG Shi-huan;LIU Jin-ling;SU Jin;HE Fu-yuan(Department of Pharmaceuties, Hunan University of Chinese Medicine, Changsha 410208, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Property and Pharmaeodaynamic Key Laboratory of Traditional Chinese Medicine, State Administration of Chinese Medicine, Changsha 410208, China;Pharmaceutical Preparation Technology and Evaluation Laboratory of Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China;Supramoleeular Mechanism and Mathematic-Physics Chraeterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha 410208, China)

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]中国中医科学院中药研究所,北京100700 [3]中药药性与药效国家中医药管理局重点实验室,湖南长沙410208 [4]湖南中医药大学现代中药制剂制备技术与评价实验室,湖南长沙410208 [5]湖南中医药大学中医药超分子机理与数理特征化实验室,湖南长沙410208

出　　处：《中国中药杂志》2018年第7期1303-1309,共7页China Journal of Chinese Materia Medica

基　　金：中央本级重大增减支项目(2060302)

摘　　要：古有《神农本草经》《本草纲目》等著作记载,人参作为上品药物,以大补元气之功效应用临床。现有文献报道,人参主要的活性成分为人参皂苷,现代研究发现人参单体皂苷对心血管相关疾病有疗效。该文拟通过中医传承辅助平台及整合药理学平台,初步阐明人参传统功效——大补元气与心血管疾病的关联性。借助中医传承辅助平台——中药成方数据库,获知人参中成药制剂治疗现代疾病的规律,从而将传统功效与现代医学相关联;并运用整合药理学平台对其药物靶标及基因功能、代谢通路富集进行分析,进一步探讨人参治疗冠心病的分子机制,旨在挖掘人参治疗冠心病的分子机制。《中药成方制剂》含人参方剂307首,主治疾病87种,人参中成药制剂主要治疗的西医疾病为冠心病;整合药理学平台分析人参治疗冠心病的分子机制发现,人参药物靶标有1 556个,其主要与线粒体呼吸过程相关。人参皂苷类化学成分Ra1,Ra2,Rb1,Rb2,Rg1,Ro等通过作用PRKAA1,PRKAA2,NDUFA4,COX5B,UQCRC1等靶标,影响趋化因子、非酒精性脂肪肝、促性腺激素、碳素代谢、糖代谢等通路间接治疗冠心病。该文初步阐明了人参多成分、多靶点、协同作用的分子机制。The ancient dragon Materia Medica,Compendium of Materia Medica and other works recorded that the main effect of ginseng is tonifying qi. It is reported that the main active ingredient of ginseng is ginsenoside. Modern studies have found that ginseng mono saponins are effective for cardiovascular related diseases. This paper preliminary clarified the efficacy of traditional ginseng-nourishing qi and cardiovascular disease through the traditional Chinese medicine（ TCM） inheritance auxiliary platform and integration platform of association of pharmacology. With the help of TCM inheritance auxiliary platform-analysis of ＂ Chinese medicine database＂,Chinese medicine treatment of modern diseases that ginseng rules,so the traditional effect associated with modern medicine and pharmacology; application integration platform enrichment analysis on the target of drug and gene function,metabolic pathway,to further explore the molecular mechanism of ginseng in the treatment of coronary heart disease,aimed at mining the molecular mechanism of ginseng in the treatment of coronary heart disease. Chinese medicine containing ginseng 307 prescriptions,87 kinds of disease indications,western medicine disease Chinese medicine therapy for ginseng main coronary heart disease; analysis of molecular mechanism of ginseng pharmacology integration platform for the treatment of coronary heart disease. Ginsenosides（ Ra1,Ra2,Rb1,Rb2,Rg1,Ro）bind these targets,PRKAA1,PRKAA2,NDUFA4,COX5 B,UQCRC1,affect chemokines,non-alcoholic fatty liver,gonadotropin,carbon metabolism,glucose metabolism and other pathways to treat coronary heart disease indirectly. The molecular mechanism of Panax ginseng＇s multi-component,multi-target and synergistic action is preliminarily elucidated in this paper.

关 键 词：人参 整合药理学 分子机制 冠心病 

分 类 号：R285[医药卫生—中药学] TP311.13[医药卫生—中医学]