百合属植物甾体皂苷成分及其药理活性研究进展  

Advances in studies on steroidal saponins and their pharmacological activities in genus Lilium

作　　者：罗林明[1,2] 覃丽 裴刚[1,2] 黄绍国[1,2] 周小江 陈乃宏[1,2,3] LUO Lin-ming;QIN Li;PEI Gang;HUANG Shao-guo;ZHOU Xiao-jiang;CHEN Nai-hong(College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China;Engineering Technology Research Center of Standardization and Function of Traditional Chinese Medicine Decoction Pieces in Hunan Province, Changsha 410208, China;Institute of Materia Mediea, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China)

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]湖南省中药饮片标准化及功能工程技术研究中心,湖南长沙410208 [3]中国医学科学院北京协和医学院药物研究所,北京100050

出　　处：《中国中药杂志》2018年第7期1416-1426,共11页China Journal of Chinese Materia Medica

基　　金：国家中医药标准化项目(ZYBZH-Y-HUN-24,ZYBZH-Y-HEB-16);湖南省中药饮片标准化及功能工程技术研究中心开放课题(BG201706);湖南省重点研发计划项目(2015SK2029);湖南省教育厅创新平台开放基金项目(15K091)

摘　　要：百合属植物中含有多种甾体皂苷成分,迄今为止已从其鳞茎中发现了至少82个甾体皂苷类化合物,其中螺甾烷醇类皂苷13个（1-13）、异螺甾烷醇类皂苷39个（14-52）、变形螺旋甾烷类皂苷7个（53-59）和呋甾烷醇类皂苷23个（60-82）。研究表明这些甾体皂苷具有多种药理活性,包括抗肿瘤、抗菌、抗炎、抗氧化、抗抑郁、保肝、降血糖、镇静催眠、抑制c AMP磷酸二酯酶及Na^＋-K^＋-ATP酶等。该文对百合属植物鳞茎中的这82个甾体皂苷类化合物及其生物活性进行分类归纳,并且分析这些化合物的结构特征以及构效关系,以期为百合的深入研究与应用开发提供参考。Genus Lilium plants contain a variety of steroidal saponins,so far at least 82 steroidal saponins have been found in the bulbs of Lilium species,including 13 spirostanol saponins（1-13）,39 isospirostanol saponins（14-52）,7 pseudospirostanol saponins（53-59）,and 23 furostanol saponins （60-82）. Studies have showed that these steroidal saponins exhibit a wide range of pharmacological activities,including antitumor,antibacterial,antiinflammatory,antioxidant,antidepressant,hepatoprotective,hypoglycemic,sedative-hypnotic effect,and inhibition of c AMP phosphodiesterase and Na^＋-K^＋ATP,et al. This paper has classified and summarized the82 steroidal saponins isolated and identified from the bulbs of Lilium species and their correlative biological activities. Also,their structural characteristics and structure-activities relationship have been discussed,which could provide references for further research and application development of Lilium plants.

关 键 词：百合属 鳞茎 甾体皂苷 药理活性 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]