纳米孔单分子传感器电导特性有限元分析  

Finite element analysis on conductance properties of nanopore single molecule sensor

作　　者：伍根生 张泓伟 于波[1] 马冬琴 宋福磊 WU Gen-sheng;ZHANG Hong-wei;YU Bo;MA Dong-qin;SONG Fu-lei(School of Mechanical and Electronic Engineering, Nanjing Forestry University, Nanjing 210037, China)

机构地区：[1]南京林业大学机械电子工程学院,江苏南京210037

出　　处：《传感器与微系统》2018年第5期19-22,共4页Transducer and Microsystem Technologies

基　　金：江苏省自然科学基金资助项目(BK20160935);江苏省属高校自然科学基金面上资助项目(16KJB460015);南京林业大学青年创新基金资助项目(CX2016027);南京林业大学大学生创新资助项目(2016NFUSPITP049)

摘　　要：主要从纳米孔结构角度,考虑生物分子在纳米孔内的位阻效应影响。运用有限元模拟方法分别模拟了3类常见纳米孔的电导,并比较了3种不同纳米孔在检测纳米杆通过纳米孔时的相对堵塞电流值大小。研究了纳米杆上带有亚结构时,在3种纳米孔内的电流堵塞效应的差异。研究方法有助于进一步理解纳米孔结构对检测生物分子的影响。Mainly consider influence of steric effect of biomolecule inside the nanopore from the perspective of nanopore structure. Finite element simulation method is used to simulate conductance of three common types of nanopore. The relative blockade current value of three nanopores while the testing nanorod is passing through the nanpores are compared. In the meantime, the difference of current blockade effect of nanorod with substructure in three nanopores is also researched . This work is helpful to understand the influence of nanopore structure on detecting biomolecules.

关 键 词：纳米孔电导 离子电流 相对堵塞电流 亚结构检测 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置]