28例梅毒患者的颅脑MRI研究  

Experimental study of brain magnetic resonance imaging in 28 patients with syphilis

作　　者：何志芳 陈亚玲[2] 吴园琴 韩亚萍 许传军[1] 张慧[1] HE Zhifang;CHEN Yaling;WU Yuanqin;HAN Yaping;XU Chuanjun;ZHANG Hui(Department of Radiology, Nanjing Second Hospital Affiliated to Southeast University, Nanjiag 210000, Jiangsu, China;Department of lnfectious Diseases, Nanjing Second Hospital Affiliated to Southeast University, Nanjing 210000, Jiangsu, China;Department of Dermatology, Nanjing Second Hospital Affiliated to Southeast University, Nanjing 210000, Jiangsu, China;Department of Infectious Diseases, Jiangbei People＇s Hospital of Nanjing, Nanjing 210048, Jiangsu, China)

机构地区：[1]东南大学附属南京第二医院放射科,南京210000 [2]东南大学附属南京第二医院感染科,南京210000 [3]东南大学附属南京第二医院皮肤科,南京210000 [4]南京江北人民医院感染科,南京210048

出　　处：《中国性科学》2018年第4期130-132,共3页Chinese Journal of Human Sexuality

基　　金：江苏省南京市医学科技发展项目(YKK14221)

摘　　要：目的:探讨28例梅毒患者颅脑MRI改变,以提高对梅毒MRI表现的认识能力。方法:选择东南大学附属南京第二医院于2013年1月至2016年12月收治的梅毒患者28例。应用全身MR扫描仪(Siemens Sonata 1.5T)扫描参数,采用3D LAVA序列动态增强扫描,对比剂为钆喷替酸葡甲胺0.1mmol/kg。且28例患者均检测脑脊液RPR和TPPA。结果:梅毒患者脑脊液RPR和TPPA阳性率均为100.00%。28例梅毒患者MRI检查脑萎缩15例、脑梗死6例、脑炎4例、正常3例。其中,脑萎缩多为显著脑萎缩;脑梗死6例中,额叶皮层下多发腔隙病灶4例,脑干梗死1例;脑炎4例中,病变仅累及双侧海马内颞叶1例,病变累及多个脑叶3例。结论:颅脑MRI检查梅毒患者可以反映颅脑表现,且可以反映病变范围,具有重要临床意义。Objective： To investigate the change in brain magnetic resonance imaging（ MRI） in 28 patients with syphilis,so as to improve the ability to recognize the MRI of syphilis. Methods： 28 patients with syphilis in Nanjing Second Hospital Affiliated to Southeast University from January 2013 to December 2016 were enrolled. The parameters of the model were simulated by 3 D LAVA,and the contrast agent was gadolinium acid and 0. 1 mmol/kg. The 28 patients were examined for cerebrospinal fluid RPR and TPPA. Results： The positive rates of RPR and TPPA in cerebrospinal fluid of patients with syphilis were 100. 00%. Among the 28 patients examined by MRI,there were 15 cases of cerebral atrophy,6 cases of cerebral infarction,4 cases of encephalitis and 3 normal cases.Among the 6 cases of cerebral infarction,there were 4 cases of cerebral fissure and a case of brain stem infarction;among the 4 cases of encephalitis,the lesion only involved in bilateral hippocampus temporal lobe in a case,and lesions involved multiple lobes in 3 cases. Conclusions： MRI examination of syphilis can reflect the brain manifestation and the scope of the disease,which has important clinical significance.

关 键 词：梅毒 颅脑 磁共振成象 

分 类 号：R445.2[医药卫生—影像医学与核医学] R759.1[医药卫生—诊断学]