针灸对关节炎大鼠炎性因子影响及抗炎镇痛机制分析  

Effect of Acupuncture and Moxibustion on Inflammatory Factors and Anti-inflammatory and Analgesic Mechanism in Rats with Arthritis

作　　者：王媛 符文彬[2] Wang Yuan;FU Wenbin(Clinic College of Acupuneture and Moxibustion, Guangzhou University of Traditional Chinese Medicine （Guangzhou Guangdong 510030, China;Department of Acupuncture and Moxibustion, Guangdong Provincial Hospital of Traditional Chinese Medicine, （Guangzhou Gguangdong 510030, China)

机构地区：[1]广州中医药大学针灸康复临床医学院,广东广州510030 [2]广东省中医院针灸科,广东广州510030

出　　处：《四川中医》2018年第5期66-68,共3页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:分析针灸对关节炎大鼠炎性因子影响及抗炎镇痛机制。方法:选取由本院实验动物中心提供Wister雄性健康大鼠40只,依据随机数字表法将大鼠分成五组,RA模型组、对照组、电针组、艾灸组和艾灸+电针组(联合组),每组各8只;常规饲养一周,大鼠消毒后弗氏完全佐剂0.1ml(含卡介苗)注入其右后足掌皮下,制作RA大鼠模型,"昆仑"穴电针与"神阙"穴艾灸来治疗,观察大鼠一般情况、足趾肿胀程度、痛阀值及血清与组织内β-内啡肽(β-Ep)水平情况。结果:造模后,模型组、电针组、艾灸组及联合组大鼠关节肿胀显著高于对照组,差异有统计学意义(P<0.05);治疗后,电针组、艾灸组及联合组大鼠关节肿胀低于模型组,联合组又低于电针组、艾灸组,差异均有统计学意义(P<0.05);造模后模型组、电针组、艾灸组及联合组大鼠痛阀对照组低,差异有统计学意义(P<0.05),治疗后电针组、艾灸组及联合组痛阀上升,和模型组对比差异有统计学意义(P<0.05);电针组、艾灸组及联合组大鼠血清β-Ep水平高于模型组,差异有统计学意义(P<0.05);模型组、电针组、艾灸组及联合组大鼠炎症组织内β-Ep水平高于对照组,电针组、艾灸组及联合组又高于模型组,联合组高于电针组及艾灸组,差异均有统计学意义(P<0.05)。结论:针灸通过使炎症组织及血清内β-Ep水平上升,来实现免疫调节与外周镇痛效果。Objective： To analyze the effect of acupuncture and moxibustion on inflammatory factors and anti-inflammatory and analgesic mechanism in rats with arthritis. Methods： By the experimental animal center of our hospital to provide healthy male Wistar 40 rats,according to the random number table method,the rats were divided into five groups： controlled group,RA model group,electro acupuncture group,moxibustion group and moxibustion＋electroacupuncture group（ combined group）,8 rats in each group,normal feeding rats a week. After disinfection of complete Freund＇s adjuvant 0. 1 ml（ including BCG） into the right postpedes subcutaneous,making RA rat model, ＂Kunlun＂and ＂Shenque＂acupoint acupuncture moxibustion treatment,observing the general condition of rats,swelling degree,pain threshold and the serum and tissues of beta endorphin（ beta-Ep level）. Results： After modeling,the model group,the electro acupuncture group,the moxibustion group joint swelling and the combined group rats were significantly higher than the controlled group,the difference was statistically significant（ P〈 0. 05）;After treatment,the electro acupuncture group,the moxibustion group and the combined group rats joint swelling compared with the model group,the combination group was lower than that of the acupuncture group and the moxibustion group（ P〈0. 05）; The model group,the electro acupuncture group,the moxibustion group and the combined group the pain threshold of rats in the controlled group（ P〈0. 05）,after the treatment of the electro acupuncture group,the moxibustion group and the combination group were statistically significant increased pain threshold,and compared with the model group the difference（ P〈0. 05）; The electro acupuncture group,the moxibustion group and the combined group rats serum-Ep level is higher than the model group（ P 〈0. 05）; beta-Ep was in high level of the model group,the electro acupuncture group,the moxibustion group and the combined group rats in inflammatory

关 键 词：类风湿性关节炎 针灸 Β-内啡肽水平 抗炎镇痛机制 

分 类 号：R245[医药卫生—针灸推拿学]