表面活性蛋白D基因多态性与肺部疾病易感性的研究进展  

Association between gene polymorphism of surfactant protein D and susceptibility to lung disease

作　　者：徐丽 谭榜宪[2] 李华[3] XU Li;TAN Bang- xian;LI Hua(North Sichuan Medical College,Nanchong, Sichuan 637000, Chin)

机构地区：[1]川北医学院临床医学院,四川南充637000 [2]川北医学院附属医院肿瘤科,四川南充637000 [3]成都军区总医院肿瘤科,四川成都610000

出　　处：《现代预防医学》2018年第11期2043-2046,共4页Modern Preventive Medicine

基　　金：四川省科技厅(2012JY0031);成都军区总医院院管课题(2011YG-B02;2013YG-A004);成都军区"十二五重大项目"(B14005)

摘　　要：目的总结表面活性蛋白D(Surfactant protein D,SP-D)基因多态性与肺部疾病易感性的研究进展。方法在Pub Med和CNKI数据库以"表面活性蛋白D"和"多态性"进行检索筛选,最终纳入28篇分析。结果 rs721917、rs1923536(丹麦人群)、rs3088308(巴基斯坦人群)与肺损伤相关;rs721917C/rs10887199C单倍型与肺气肿相关(日本人群);rs721917在内的多个位点与高加索人群和亚洲人群的慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)相关;rs721917T/rs10887199C单倍型与间质性肺炎相关;此外,rs721917位点还与哮喘及肺部感染性疾病风险相关。结论SP-D基因多态性与多种肺部疾病易感性相关,将有助于识别疾病的风险人群,促进疾病预防。Objective To summarize the research progress of the polymorphism of surface active protein D （ SP - D） gene and susceptibility to lung diseases. Methods Papers were retrieved with key words ＂surfactant protein D＂ and ＂polymorphism＂ in PubMed and CNKI database. Finally,28 papers were analyzed. Results The rs721917 （ Danish）, rs1923536 （ Danish）, rs3088308 （Pakistan） were associated with lung injury. Haplotype rs721917C/rs10887199C was associated with emphysema （Japanese） ~ Multiple sites including rs721917 were associated with Chronic obstructive pulmonary disease （COPD）among Caucasian population and Asians. Haplotype rs721917T/rs10887199C was associated with interstitial pneumonia. Besides,rs721917 was also associated with asthma and lung infection. Conclusion The polymorphism of SP - D gene is associated with lung diseases. It may help distinguish the risk population and facilitate prevention of lung injuries.

关 键 词：表面活性蛋白D SP-D 多态性 

分 类 号：R115[医药卫生—公共卫生与预防医学]