温胆汤加减方治疗冠心病Meta分析  

Meta-analysis on Wendan Decoction in Treatment of Coronary Heart Disease

作　　者：赵志玥 张明雪[1] 邹宏[1] 李扬 尹丽雯 ZHAO Zhiyue;ZHANG Mingxue;ZOU Hong;LI Yang;YIN Liwen(Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning, China)

机构地区：[1]辽宁中医药大学

出　　处：《辽宁中医药大学学报》2018年第4期97-103,共7页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81273698);辽宁省中医药临床学(专)科能力建设项目(2012-lnzyxzk-01);辽宁省人文社会科学基金项目(L05czx025);沈阳市科技计划项目(F12-155-9-00);辽宁省特聘教授和辽宁中医药大学青蓝学者工程基金资助项目

摘　　要：目的：系统评价温胆汤加减方治疗冠心病的临床疗效。方法：计算机检索Cochrane Library、Pubmed、Medline、CNKI（中国知网全文数据库）、WF（万方数据库）、VIP（维普中文科技期刊数据库）中的文献,检索时间为自建库至2017年4月20日。由2名评价者按照一定的纳入和排除标准独立提取文献资料,交叉核对,并按照Jadad评分进行文献质量评价,对于所纳入的文献使用由Cochrane协作网提供的Rev Man5.3 Meta分析软件进行统计分析。结果：共纳入31项研究（共2562例患者）,Meta分析结果显示：与西医常规治疗相比,温胆汤加减方联合西医常规治疗在冠心病临床疗效、心电图和心绞痛疗效,以及在改善冠心病患者中医证候积分、TC、TG、LDL-C、HDL-C、C反应蛋白（CRP）方面的差异性均具有统计学意义;温胆汤加减方与西医常规治疗相比,在冠心病临床疗效、TC、TG的改善方面其差异性均不存在统计学意义,但在心电图疗效、LDL-C的改善方面其差异性具有统计学意义;与硝酸异山梨酯相比,温胆汤加减方在冠心病临床疗效、心绞痛疗效,以及在低切、血浆黏度、红细胞压积方面的差异性均具有统计学意义,而在心电图疗效方面其差异性不存在统计学意义;与丹参片相比,温胆汤加减方在冠心病临床疗效及心电图疗效方面的差异性具有明显的统计学意义。结论：温胆汤加减方与西医常规治疗联用比单纯西医常规治疗更能有效改善冠心病的症状、心电图、心绞痛、血脂和CRP指标;单独运用温胆汤加减方在改善心电图情况和降低LDL-C方面的疗效同样优于西医常规治疗;温胆汤加减方比硝酸异山梨酯更能有效改善冠心病临床疗效、心绞痛疗效和血液流变学指标;温胆汤加减方在冠心病临床疗效以及心电图疗效方面优于丹参片。Objective：To evaluate the efficacy of Wendan Decoction in treatment of coronary heart disease. Methods：Cochrane library,Pubmed,Medline,CNKI,WF,VIP Database were searched until 20 th April,2017 with computer. The data was chosen and extracted by two reviewers independently according to inclusion and exclusion criteria and cross-checked,and assessed by Jadad score questionnaire in the quality and methodology. The data which was chosen should be analyzed by the software of Rev Man 5.3 which was provided by Cochrane Collaboration Network. Results：There are totally 31 trials and 2562 patients included. The results of the Meta analysis are shown as below. Compared with conventional Western medicine,Wendan Decoction combined with conventional Western medicine has significantly different with clinical efficacy of coronary heart disease,ECG,angina pectoris,and in the improvement of TCM syndrome points,TC,TG,LDL-C,HDL-C,CRP,and Wendan Decoction has not significantly different with clinical efficacy of coronary heart disease,TC,TG but has significantly different with ECG,LDL-C. Compared with isosorbide dinitrate,Wendan Decoction has significantly different with clinical efficacy of coronary heart disease,angina pectoris,low cut,plasma viscosity,hematocrit,but is not significantly different with ECG. Compared with danshen tablets,Wendan Decoction has significantly different with clinical efficacy of coronary heart disease,ECG. Conclusion：Wendan Decoction combined with conventional Western medicine is better than conventional Western medicine in the aspect of changing the symptoms of coronary heart disease,ECG,angina pectoris,blood lipids,CRP. Wendan Decoction is better than conventional Western medicine in the aspect of changing the results of ECG and lowering the value of LDL-C. It is better tan isosorbide dinitrate in the aspect of clinical efficacy of coronary heart disease,angina pectoris,hemorheology index. And it is also better than danshen tablets in the aspect of clinical efficacy of coronary heart disease an

关 键 词：温胆汤加减方 冠心病 META分析 系统评价 

分 类 号：R541.4[医药卫生—心血管疾病]