川芎嗪注射液对急性心肌梗死大鼠心肌损伤标志物及心功能的影响  

Effect of Ligustrazine injection on myocardial injury markers and cardiac function in rats with acute myocardial infarction

作　　者：张晓东[1] 袁权[1] 林德智[1] 张少利[2] ZHANG Xiao-Dong;YUAN Quan;LIN De-Zhi;ZHANG Shao-Li(Department of Cardiology, First People＇s Hospital of Neijiang, Neijiang, Sichuan 641000, China;Department of Cardiology, the First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453100, China)

机构地区：[1]四川省内江市第一人民医院心内科,四川省内江市641000 [2]新乡医学院第一附属医院心内科,河南省新乡市453100

出　　处：《中国动脉硬化杂志》2018年第5期474-478,共5页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨川芎嗪注射液对急性心肌梗死大鼠心肌损伤标志物及心功能的影响。方法选择36只SD雄性大鼠作为实验动物,随机分为对照组、模型组和干预组,每组12只。模型组和干预组建立急性心肌梗死（AMI）模型,干预组给予川芎嗪注射液治疗。干预后1周和3周时,行心脏彩色超声以测定心功能指标,采集血清并测定心肌损伤标志物以及氧化应激指标。结果每组大鼠均存活10只。干预后1周和3周时,模型组左心室舒张末期内径（LVEDd）、左心室收缩末期内径（LVESd）均明显高于对照组,左心室射血分数（LVEF）明显低于对照组（P〈0.05）;干预组LVEDd、LVESd均明显低于模型组,LVEF明显高于模型组（P〈0.05）。干预后1周时,模型组血清肌酸激酶同工酶（CK-MB）、心肌肌钙蛋白Ⅰ（cTnⅠ）、心肌肌钙蛋白T（cTnT）含量明显高于对照组（P〈0.05）;干预组血清CK-MB、cTnⅠ、cTnT含量明显低于模型组（P〈0.05）。干预后3周时,模型组血清cTnⅠ、cTnT含量明显高于对照组（P〈0.05）;干预组大鼠血清cTnⅠ、cTnT含量明显低于模型组（P〈0.05）。干预后1周和3周时,模型组血清丙二醛（MDA）含量明显高于对照组,超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）含量明显低于对照组（P〈0.05）;干预组血清MDA含量明显低于模型组,SOD、GSH-Px含量明显高于模型组（P〈0.05）。结论川芎嗪注射液能够减轻AMI大鼠的心肌细胞损伤以及氧化应激反应,改善心功能。Aim To investigate the effect of Ligustrazine injection on myocardial injury markers and cardiac function in rats with acute myocardial infarction. Methods 36 male SD rats were selected as experimental animal and randomly divided into control group,model group and intervention group,12 animals in each group. Model group and intervention group were used to establish acute myocardial infarction（ AMI） model,and intervention group was treated with ligustrazine injection. At 1 week and 3 weeks after intervention,the cardiac color doppler echocardiography was performed to measure the cardiac function,and serum was collected for the determination of myocardial injury markers and oxidative stress indexes. Results 10 rats were survived in each group. At 1 week and 3 weeks after intervention,left ventricular end-diastolic diameter（ LVEDd） and left ventricular end-systolic dimension（ LVESd） in model group were significantly higher than those in control group,and left ventricular ejection fraction（ LVEF） in model group was significantly lower than that in control group（ P〈0. 05）; LVEDd and LVESd in intervention group were significantly lower than those in model group,and LVEF was significantly higher in intervention group than that in model group（ P〈0.05）. At 1 week after intervention,serum creatine kinase isoenzyme MB（ CK-MB）,cardiac troponin Ⅰ（ cTnⅠ） and cardiac troponin T（ cTnT） contents in model group were significantly higher than those in control group（ P〈0.05）; Serum CK-MB,cTnⅠ,cTnT contents in intervention group were significantly lower than those in model group（ P〈0.05）. At 3 weeks after intervention,serum cTnⅠ and cTnT contents in model group were significantly higher than those in control group（ P〈0. 05）; Serum cTnⅠ and cTnT contents in intervention group were significantly lower than those in model group（ P〈0.05）. At 1 week and 3 weeks after intervention,serum malondialdehyde（ MDA） contents in model group was significantly higher than t

关 键 词：急性心肌梗死 川芎嗪 心肌损伤 氧化应激 心功能 

分 类 号：R54[医药卫生—心血管疾病]