When and how does brain-derived neurotrophic factor activate Nrf2 in astrocytes and neurons？  

作　　者：Tetsuro Ishii Giovanni E.Mann 

机构地区：[1]University of Tsukuba, Tsukuba, Japan [2]School of Cardiovascular Medicine and Sciences, King's British Heart Foundation Centre of Excellence, Faculty of Life Sciences and Medicine, King's College I,ondon, London, UK

出　　处：《Neural Regeneration Research》2018年第5期803-804,共2页中国神经再生研究（英文版）

基　　金：support of JSPS KAKENHI Grant Number 21500386 (TI);British Heart Foundation (GEM, FS/15/31298; FS/16/67/32548)

摘　　要：Circadian rhythm protects neurons：Although the master clock entrains the whole body rhythm,peripheral tissues also express core clock transcription factors Clock and Bmal1,which regulate expression of clock genes including Period（Per）and Cryptochrome（Cry）proteins.Complexes of Per and Cry proteins repress Bmal1-and Clock-mediated transcription forming a negative feedback loop,which regulates nearly a 24 hours self-sustained rhythm including energy metabolism.Circadian rhythm protects neurons：Although the master clock entrains the whole body rhythm,peripheral tissues also express core clock transcription factors Clock and Bmal1,which regulate expression of clock genes including Period（Per）and Cryptochrome（Cry）proteins.Complexes of Per and Cry proteins repress Bmal1-and Clock-mediated transcription forming a negative feedback loop,which regulates nearly a 24 hours self-sustained rhythm including energy metabolism.

关 键 词：When and how does brain-derived neurotrophic factor activate Nrf2 in astrocytes and neurons NGF 

分 类 号：R338[医药卫生—人体生理学]