Dynamic correlation of diffusion tensor imaging and neurological function scores in beagles with spinal cord injury  

作　　者：Chang-Bin Liu De-Gang Yang Qian-Ru Meng Da-Peng Li Ming-Liang Yang Wei Sun Wen-Hao Zhang Chang Cai Liang-Jie Du Jun Li Feng Gao Yan Yu Xin Zhang Zhen-Tao Zuo Jian-Jun Li 

机构地区：[1]School of Rehabilitation Medicine, Capital Medical University, Department of Spinal and Neural Function Reconstruction, China Rehabilitation Research Center, Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, China Rehabilitation Science Institute, Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China [2]State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China,The Innovation Center of Excellence on Brain Science, Chinese Academy of Sciences, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China

出　　处：《Neural Regeneration Research》2018年第5期877-886,共10页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.81272164;the Special Fund for Basic Scientific Research of Central Public Research Institutes in China,No.2015CZ-6,2016CZ-4;the Beijing Institute for Brain Disorders in China,No.201601,0000-100031;the Supporting Program of the “Twelve Five-year Plan” for Science&Technology Research of China,No.2012BAI34B02;a grant from the Ministry of Science and Technology of China,No.2015CB351701

摘　　要：Exploring the relationship between different structure of the spinal cord and functional assessment after spinal cord injury is important. Quantitative diffusion tensor imaging can provide information about the microstructure of nerve tissue and can quantify the pathological damage of spinal cord white matter and gray matter. In this study, a custom-designed spinal cord contusion-impactor was used to damage the T_（10） spinal cord of beagles. Diffusion tensor imaging was used to observe changes in the whole spinal cord, white matter, and gray matter, and the Texas Spinal Cord Injury Score was used to assess changes in neurological function at 3 hours, 24 hours, 6 weeks, and 12 weeks after injury. With time, fractional anisotropy values after spinal cord injury showed a downward trend, and the apparent diffusion coefficient, mean diffusivity, and radial diffusivity first decreased and then increased. The apparent diffusion-coefficient value was highly associated with the Texas Spinal Cord Injury Score for the whole spinal cord（R = 0.919, P = 0.027）, white matter（R = 0.932, P = 0.021）, and gray matter（R = 0.882, P = 0.048）. Additionally, the other parameters had almost no correlation with the score（P 〉 0.05）. In conclusion, the highest and most significant correlation between diffusion parameters and neurological function was the apparent diffusion-coefficient value for white matter, indicating that it could be used to predict the recovery of neurological function accurately after spinal cord injury.Exploring the relationship between different structure of the spinal cord and functional assessment after spinal cord injury is important. Quantitative diffusion tensor imaging can provide information about the microstructure of nerve tissue and can quantify the pathological damage of spinal cord white matter and gray matter. In this study, a custom-designed spinal cord contusion-impactor was used to damage the T_（10） spinal cord of beagles. Diffusion tensor imaging was used to observe changes in the whole spinal cord, white matter, and gray matter, and the Texas Spinal Cord Injury Score was used to assess changes in neurological function at 3 hours, 24 hours, 6 weeks, and 12 weeks after injury. With time, fractional anisotropy values after spinal cord injury showed a downward trend, and the apparent diffusion coefficient, mean diffusivity, and radial diffusivity first decreased and then increased. The apparent diffusion-coefficient value was highly associated with the Texas Spinal Cord Injury Score for the whole spinal cord（R = 0.919, P = 0.027）, white matter（R = 0.932, P = 0.021）, and gray matter（R = 0.882, P = 0.048）. Additionally, the other parameters had almost no correlation with the score（P 〉 0.05）. In conclusion, the highest and most significant correlation between diffusion parameters and neurological function was the apparent diffusion-coefficient value for white matter, indicating that it could be used to predict the recovery of neurological function accurately after spinal cord injury.

关 键 词：nerve regeneration spinal cord injury diffusion tensor imaging fractional anisotropy apparent diffusion coefficient white matter gray matter Texas Spinal Cord Injury Score beagles neural regeneration 

分 类 号：R651.2[医药卫生—外科学]